Bio-Instructive Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine

Bio-Instructive Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine explores musculoskeletal tissue growth and development across populations, ranging from elite athletes to the elderly. The regeneration and reparation of musculoskeletal tissues present the unique challenges of requiring both the need to withstand distinct forces applied to the body and ability to support cell populations.

The book is separated into sections based on tissue type, including bone, cartilage, ligament and tendon, muscle, and musculoskeletal tissue interfaces. Within each tissue type, the chapters are subcategorized into strategies focused on cells, hydrogels, polymers, and other materials (i.e. ceramics and metals) utilized in musculoskeletal tissue engineering applications.

In each chapter, the relationships that exist amongst the strategy, stem cell differentiation and somatic cell specialization at the intracellular level are emphasized. Examples include intracellular signaling through growth factor delivery, geometry sensing of the surrounding network, and cell signaling that stems from altered population dynamics.

Presents a self-contained work for the field of musculoskeletal tissue engineering and regenerative medicineFocuses on how materials of structures can be designed to be resistant while promoting viable graftsContains major tissue types that are covered with a strategy for each material and structure

Part I: Introduction

Chapter 1: Bio-Instructive Cues in Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine

Chapter 2: Functionalizing With Bioactive Peptides to Generate Bio-Instructive Scaffolds

Part II: Bone

Chapter 3: Bio-Instructive Scaffolds for Bone Regeneration

Part III: Tendon/Ligament

Chapter 4: Bio-Instructive Scaffolds for Tendon/Ligament Regeneration

Part IV: Cartilage

Chapter 5: Bio-Instructive Scaffolds for Cartilage Regeneration

Part V: Muscle

Chapter 6: Ultrastructure and Biomechanics of Skeletal Muscle ECM: Implications in Tissue Regeneration

Chapter 7: Bio-Instructive Scaffolds for Muscle Regeneration: NonCrosslinked Polymers

Chapter 8: Bio-Instructive Scaffolds for Skeletal Muscle Regeneration: Conductive Materials

Part VI: Musculoskeletal Interfaces

Chapter 9: Bio-Instructive Scaffolds for Musculoskeletal Interfaces