Structural Biology in Immunology: Structure/Function of Novel Molecules of Immunologic Importance

Structural Biology in Immunology, Structure/Function of Novel Molecules of Immunologic Importance delivers important information on the structure and functional relationships in novel molecules of immunologic interest. Due to an increasingly sophisticated understanding of the immune system, the approach to the treatment of many immune-mediated diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease has been dramatically altered. Furthermore, there is an increasing awareness of the critical role of the immune system in cancer biology. The improved central structure function relationships presented in this book will further enhance our ability to understand what defects in normal individuals can lead to disease.

Describes novel/recently discovered immunomodulatory proteins, including antibodies and co-stimulatory or co-inhibitory moleculesEmphasizes new biologic and small molecule drug design through the exploration of structure-function relationshipFeatures a collaborative editorial effort, involving clinical immunologists and structural biologistsProvides useful and practical insights on developing the necessary links between basic science and clinical therapy in immunologyGives interested parties a bridge to learn about computer modeling and structure based design principles

1. Organization of Immunological Synapses and Kinapses 2. Principles of Protein Recognition by Small T-Cell Adhesion Proteins and Costimulatory Receptors 3. Synthetic Antibody Engineering: Concepts and Applications 4. Natural Killer Cell Receptor 5. Structure-Function in Antibodies to Double-Stranded DNA 6. The Role of the Constant Region in Antibody-Antigen Interactions: Redefining the Modular Model of Immunoglobulin Structure