The Origin of Chronic Inflammatory Systemic Diseases and their Sequelae

Chronic inflammatory diseases such as rheumatoid arthritis, ankylosing spondylitis, multiple sclerosis, inflammatory bowel diseases, and others typically stimulate a systemic response of the entire body. This response has a uniform character in many diseases because common pathways are switched on. The uniform response regulates systemic energy and water provision. However, long-term application of this program leads to typical disease sequelae such as fatigue / depressive symptoms, sleep disturbances, anorexia, malnutrition, muscle wasting – cachexia, cachectic obesity, insulin resistance, dyslipidemia, alterations of steroid hormone axes, disturbances of the hypothalamic-pituitary-gonadal axis, elevated sympathetic tone, hypertension, volume expansion, decreased parasympathetic tone, inflammation–related anemia, bone loss, hypercoagulability, circadian rhythms of symptoms, and disease exacerbation by stress .

The Origin of Chronic Inflammatory Systemic Diseases and Their Sequelae demonstrates concepts of neuroendocrine immunology, energy and water regulation, and evolutionary medicine in order to show that the uniform response that regulates systemic energy and water provision, has been positively selected for acute physiological responses and short-lived disease states, but is a misguided program in chronic inflammatory diseases and aging.

Offers a broad conceptual framework with a strong clinical link, written in an easy to grasp style and demonstrating the link to aging researchDescribes the important principles derived from basic immunology that are used to explain pathogenesis of chronic inflammatory systemic diseases with a focus on autoimmunityDefines the bioenergetics and energy regulation of the body explaining common response pathways typical for systemic inflammationMakes use of evolutionary medicine theory to demonstrate the uniformity of the systemic responseExplains the appearance of typical disease sequelae on the basis of the three pillars: neuroendocrine immunology, energy regulation, and evolutionary medicine theoryContains color figures and tables that explain the field to newcomers

1. History of immunology research and relevance for chronic inflammatory systemic diseases
2. Pathogenic concepts from psycho-neuroendocrine immunology
3. Energy and volume regulation and chronic inflammatory systemic disease
4. Evolutionary medicine and chronic inflammatory systemic disease
5. Typical disease sequelae in chronic inflammatory systemic diseases
6. Aging related sequalae – inflammaging
7. Continuation and synchronization