Immune Rebalancing: The Future of Immunosuppression

Immune Rebalancing: The Future of Immunosuppression summarizes the most promising perspectives of immunopharmacology, in particular in the area of immunosuppression by considering molecular pathways, personalized medicine, microbiome and nanomedicine.

Modulation of immune responses for therapeutic purposes is a particularly relevant area, given the central role of anomalous immunity in diseases. These diseases vary from the most typically immune-related syndromes (autoimmune diseases, allergy and asthma, immunodeficiencies) to those in which altered immunity and inflammation define the pathological outcomes (chronic infections, tumours, chronic inflammatory and degenerative diseases, metabolic disorders, etc.

Visits immunosuppression from a modern point of view of signalling mechanisms at the light of the current knowledge of signalling mechanisms and regulatory networks allows the reader to formulate new ideas and concepts on how to use immunosuppression the therapeutic purposesEncourages researchers to engage into exploring the field of pharmacological modulation of immune responses in depth, and with the new knowledge and tools available, designs more effective therapeutic strategies to autoimmune and inflammatory diseases, cancer, degenerative diseases and infectionsExamines the link between molecular pathways associated to immune-suppression and the new immunopharmacology approachesProvides information on the new strategies for drug development in this fieldConsiders the role of microbes in the development of the mammalian immune system and immune responses, which will widen the reader’s strategy for addressing therapeutic immune modulations

1. Pharmacological strategies using biologics as immunomodulatory agents (Introduction)
2: Mechanisms of immune-related pathologies and their current treatment
2.1 Rheumatoid arthritis
2.2 IBD and Crohn’s disease
2.3 MS and neurodegenerative diseases
2.4 Allergic diseases
2.5 Cancer
3: Biologics as immunosuppressive agents
3.1 Modulating macrophage activity
3.2 Modulatig inflammatory cytokines: IL-1
4. Systems medicine and personalised medicine
5. Modulation of the microbiome for immune re-balancing
6. Natural products
7. Nanomedicine