Oxidative Stress and Biomaterials

Oxidative Stress and Biomaterials provides readers with the latest information on biomaterials and the oxidative stress that can pose an especially troubling challenge to their biocompatibility, especially given the fact that, at the cellular level, the tissue environment is a harsh landscape of precipitating proteins, infiltrating leukocytes, released oxidants, and fluctuations of pH which, even with the slightest shift in stasis, can induce a perpetual state of chronic inflammation.

No material is 100% non-inflammatory, non-toxic, non-teratogenic, non-carcinogenic, non-thrombogenic, and non-immunogenic in all biological settings and situations.

In this embattled terrain, the most we can hope for from the biomaterials we design is a type of “meso-compatibility,” a material which can remain functional and benign for as long as required without succumbing to this cellular onslaught and inducing a local inflammatory reaction.

Explores the challenges of designing and using biomaterials in order to minimize oxidative stress, reducing patterns of chronic inflammation and cell deathBrings together the two fields of biomaterials and the biology of oxidative stressProvides approaches for the design of biomaterials with improved biocompatibility

Section I. Basic Principles and Current Understanding
Chapter 1. Free Radical Chemistry Primer
Chapter 2. Oxidative stress, Inflammation and Disease
Chapter 3. Biomaterial Biocompatibility: Current Understanding and Basics
Chapter 4. Oxidative Stress and Biomaterials: The Inflammatory Link
Chapter 5. Nanoparticle Toxicity and Environmental Impact
Section II. Analytical Tools
Chapter 6. In Vitro –Cell Free Systems for Oxidative stress analysis
Chapter 7. In Vitro- Cellular Assay for Oxidative stress and Biomaterial Response
Chapter 8. In Vivo Assays for Oxidative stress and Biomaterial Biocompatibility
Chapter 9. Emerging Technologies and needs in Oxidative stress analysis
Section III. Incorporating Oxidative Stress into Biomaterial Design
Chapter 10. Oxidation State as a Bioresponsive Trigger
Chapter 11. Antioxidant Polymers as a Biomaterial or Therapeutic choice
Chapter 12. Metal Nanoparticle Antioxidants
Chapter 13. Oxidative Stress and Cancer Therapy
Chapter 14. Immunomodulatory Biomaterials