Medical Epigenetics

Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases. The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many others directly involved with health care, but also investigators in life sciences, biotech companies, graduate students and many others who are interested in more applied aspects of epigenetics. Research in the area of translational epigenetics is a cornerstone of this volume.

Critical reviews dedicated to the burgeoning role of epigenetics in medical practiceCoverage of emerging topics including twin epigenetics as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicineEncompasses a disease-oriented perspective of medical epigenetics as well as diagnostic and prognostic epigenetic approaches to applied medicine

Section I:  Overview

1.  An Overview of Medical Epigenetics  Trygve O. Tollefsbol

Section II:  Basic Principles of Epigenetics

2.  DNA Methylation:  Basic Principles  Cynthia A. Moylan and Susan K. Murphy

3.  Histone-deacetylases as a therapeutic target in neurodegenerative diseases  Farahnaz Sananbenesi and Andre Fischer

4.  Basic principles of noncoding RNAs in epigenetics  Ilaria Panzeri, Grazisa Rossetti and Massimiliano Pagani

Section III:  General Medical Aspects of Epigenetics

5.  Epidemiological Epigenetics in Medicine  Alexander  Vaiserman

6.  Lifestyle and Preventive Medical Epigenetics  Marcus V. Gomes

7.  Environmental Medical Epigenetics: A Review of Epigenetically-induced Medical Risks Generated from Exposures in Our Air, Food, and Personal Products  Rachel L. Miller

8.  Behavioral Medical Epigenetics  Olivia H. Cox and Richard S. Lee

9.  Medical Epigenetics in Twins  Joel C. Eissenberg

10.  Epigenetic Biomarkers of Disease  Philip D. Voyias, Abhilasha Patel and Ramesh P. Arasaradnam

11.  Prognostic Epigenetics  Anup Sharma, Eihab Abdelfatah, Maryam Al Eissa and Nita Ahuja

Section IV:  Epigenetics of System Disorders

12.  Immune System Disorders and Epigenetics  Stuti Mehta and Kate L. Jeffrey

13.  Pulmonary Diseases and Epigenetics  Hong Peng, Dandan Zong, Zijing Zhou and Ping Chen

14.  Cardiovascular Disorders and Epigenetics  Charbel Abi Khalil

15.  Epigenomics of Intestinal Disease  Daniel Rory Kelly and Theresa Alenghat

16.  Epigenetics of Skin Disorders  Shuaihantian Luo and Qianjin Lu

17.  Epigenetics in Bone and Joint Disorders  N. Altorok, S. Nada, V. Nagaraja and Bashar Kahaleh

18.  Epigenetics of Muscle Disorders  Viviana Moresi, Nicoletta Marroncelli, Eva Pigna and Sergio Adamo

19.  Epigenetics of Psychiatric Disorders  Marija Kundakovic

20. Epigenetic Alterations in Endocrine-dependent Cancers:  Implications of Endocrine Dysfunctions   Genevieve Deblois and Mathieu Lupien

21.  Reproductive Disease Epigenetics   Rafael Oliva*

22.  Epigenetics in Ocular Medicine  Verity F. Oliver, Katherine A. van Bysterveldt and Shannath L. Merbs*

Section V:  Multi-system Medical Epigenetics

23.  Pediatric Diseases and Epigenetics  Judith G. Hall*

24.  Epigenetics of Infectious Diseases  Kate L. Seib and Michael P. Jennings

25.  Clinical Utility of Solid Tumor Epigenetics  Søren Kristiansen and György Sölétormos

26.  Epigenetic Control in Human Normal Follicular Thyroid Cells and in Thyroid Carcinoma  Zeus Andrea Antonello and Carmelo Nucera

27.  Epigenetics in Acute Myeloid Leukemia  Cristina Giorgio, Carmela Dell’Aversana and Lucia Altucci

28.  Epigenetic Regulation in Cancer Metastasis  Huan Wang, Yukun Zhang, Adam Kriska and Hong Chen

29.  Epigenetics in Exercise Science and Sports Medicine  Philipp Zimmer, Alexander Schenk and Wilhelm Bloch

30.  Epigenetic Mechanisms and Inheritance of Acquired Susceptibility to Disease  Rajesh C. Miranda, Nihal A. Salem, Annette S. Fincher, Amanda H. Mahnke and Sasha G. Burrowes

Section VI.  Pharmacology of Epigenetics

31.  Toxicology and Epigenetics  Jian Tajbakhsh and Jatinder Singh

32.  Pharmacoepigenomics  Ramón Cacabelos and Clara Torrellas

Section VII:  Therapeutic Epigenetics

33.  Therapeutics and DNA Methylation Inhibitors  Sheena Bhalla and Shyamala C. Navada

34.  Histone Deacetylase Inhibitors in Medical Therapeutics  Pusoon Chun

35.  NAD+-dependent Deacetylases and Medical Therapy  Ashok Kumar, Louisa Ben-Aderet, Jinan Elayan and Mona Dvir-Ginzberg*

36.  Experimental Approaches Towards Histone Acetyltransferase Inhibitors as Therapeutics  H. Wapenaar and Frank J. Dekker

37.  Histone Methylation Modifiers in Medical Therapeutics  Patrick Trojer   38.  Therapeutics of Epigenetic-based RNA molecules  Costas Koufaris* and Vicky Nicolaidou

39.  Natural Epigenetic-modifying Molecules in Medical Therapy  Avinash Kumar, Nasir A. Butt and Anait S. Levenson

40.  Outcome of Combining Epigenetic Drugs with Other Treatments in the Clinic  Paromita Raha

41.  Epigenetics of Pain Management  Beverley Greenwood-Van Meerveld, Dawn Prusator, Casey Ligon, Anthony C. Johnson and Rachel D. Moloney

42.  Personalized Epigenetics  Michael Bitzer and Nisar P. Malek

43.  Epigenetics and Regenerative Medicine: Neural and Skeletal Muscle Perspectives  Constantin Heil and Daniela Palacios

44.  Stem Cell Epigenetics in Medical Therapy  Baoli Cheng, Liqi Shu and Peng Jin

Section VIII:  Medical Epigenetics:  Future Prospects

45.  Prospective Advances in Medical Epigenetics  Junjie Xiao and Guoping Li