Mesenchymal Stromal Cells as Tumor Stromal Modulators

Mesenchymal stromal/ stem cells (MSCs) represent a heterogeneous cell population with immunomodulating, tissue repairing, differentiating, migratory and angiogenic abilities, making them important tools for clinical and translational research. An understanding of the role of MSCs in modulating tumor growth provides a glimpse into their role in non-pathological tissue remodeling and potential regenerative tissue therapies.

Mesenchymal Stromal Cells as Tumor Stromal Modulators is a comprehensive source for the understanding of the role of MSCs as ubiquitous connective tissue cell components, which may have both direct and indirect effects on the tumor microenvironment and potential for regenerative therapeutics for various diseases. Using cancer as a model disease, this book explores the transformative role MSCs play in the recruitment of disease cells, cell repair and immunological defenses.

Explores the biology of mesenchymal stromal cells (MSCs) and tissue related functionDiscusses the bidirectional communication between tumor stroma and MSCs derived from bone marrow, from adipose tissue and from other tissue typesProvides in-depth analysis of the effects of MSCs on key processes that regulate disease progression, such as angiogenesis, metastatic potential, invasion, proliferation, tumor immune privileges

1. What are Mesenchymal Stromal Cells? Origin and Discovery of Mesenchymal Stromal Cells Jorge Domenech

2. Mesenchymal Stem/Stromal Cells from Adult Tissues Regina Coeli dos Santos Goldenberg, Debora Bastos Mello and Karina Dutra Asensi

3. Mesenchymal Stem/Stromal Cells from Neonatal Tissues Alp Can, Zeynep Gulhan Yigman

4. Mesenchymal stem/Stromal Cells Derived from Pluripotent Stem Cells Carlos Luzzani, Santiago G. Miriuka

5. Mesenchymal Stem/Stromal Cells as Biological Factories Addeli Bez Batti Angulski, Alejandro Correa, Marco Augusto Stimamiglio

6. MSC recruitment from distant and local tissues in homeostasis and tissue remodeling Lindolfo da Silva Meirelles, Nance Beyer Nardi

7. Mesenchymal stem/stromal cell trafficking and homing Armel Herve Nwabo Kamdje, Paul Faustin Seke Etet, Paul Takam Kamga, Jean Marc Muller, Giulio Bassi, Erique Lukong, Raghuveera Kumar Goel, Mauro Krampera

8. Tumor-Secreted Factors That Induce Mesenchymal Stromal Cell Chemotaxis Kevin Anton and John Glod

9. Mesenchymal stromal cells recruitment by gastrointestinal carcinomas Guillermo D. Mazzolini

10. Mesenchymal Stem/Stromal Cell  Recruitment by Central Nervous System Tumors Brittany C. Parker Kerrigan and Frederick F. Lang

11. Mesenchymal stem cell transition to tumor-associated stromal cells contributes to cancer progression Karen M. Bussard,Erika Spaeth, Lysette A. Mutkus, Kristina A. Stumpf and Frank C. Marini

12. Mesenchymal Stromal Cells and Tumor Angiogenesis Shih-Chieh Hung

13. Role of MSCs in Anti-Tumor Drug Resistance Augustin Le Naour and Bettina Couderc

14. Multifunctional Roles of Tumor-Associated Mesenchymal Stem Cells in Cancer Progression Antoine E. Karnoub 15. Mesenchymal Stem Cells and Metastatic Niches Leandro Marcelo Martinez, Vivian Labovsky, Valeria Beatriz Fernández Vallone, Choi Hosoon,  Mariana Amorós, Casie Phillips  and Norma Alejandra Chasseing

16. The bone marrow microenvironment as a regulator of tumor dormancy Makiko Ono and Takahiro Ochiya

17. MSC and the tumor immune system Nykia D. Walker, George R. Nahas, Jessian Munoz, Justin Lucas, Piotr Pobiarzyn and Pranela Rameshwar

18. The inflammatory environment and its effects on mesenchymal stem cells Krisztian Nemeth

19. All Aboard: Mesenchymal Stem Cells as Cell Carriers for Virotherapy Julius W. Kim, Jason Murphy, Alan L. Chang, DrewA. Spencer, J. Robert Kane,DeepakKanojia,  Aida Rashidi, Jacob S. Young and Maciej S. Lesniak

20. Engineered Mesenchymal Stem/ Stromal Cells for Cellular Therapies Sreevidhya Ramakrishnan, Debanjan Sarkar

21. Extracellular Vesicles from Mesenchymal Stem Cells and their potential in Tumor Therapy Johann Mar Gudbergsson and Meg Duroux

22. MSCs therapy: defining the risks of MSC therapy. Ex vivo expanded MSCs for therapeutic purposes Myriam N. Bouchlaka, Peiman Hematti and Christian M. Capitini

23. Concluding Remarks Mariana Garcia and Marcela Bolontrade