Neuroepidemiology

Neuroepidemiology covers the foundations of neuroepidemiological research and the epidemiology of disorders primarily affecting the nervous system, as well as those originating outside the nervous system. The etiology of many important central nervous system disorders remains elusive. Even with diseases where the key risk determinants have been identified, better prevention and therapy is needed to reduce high incidence and mortality. Although evolving technologies for studying disease provide opportunities for such, it is essential for researchers and clinicians to understand how best to apply such technology in the context of carefully characterized patient populations.

By paying special attention to methodological approaches, this volume prepares new investigators from a variety of disciplines to conduct epidemiological studies in order to discern the etiologic factors and underlying mechanisms that influence the onset, progression, and recurrence of CNS disorders and diseases. The book also provides current information on methodological approaches for clinical neurologists seeking to expand their knowledge in research.

Includes coverage of the foundations of neuroepidemiological research and the epidemiology of disorders primarily affecting the nervous system, as well as those originating outside the nervous systemDescribes the most recent methodologies to define and quantify the burden of CNS disorders and to understand the underlying mechanisms, with neuroimaging and molecular methods receiving particular emphasisOffers extensive description of those neurological conditions that are secondary to other diseases whose incidence is on the rise because of longer survival ratesFeatures chapters authored by leaders in the field from around the globe

SECTION 1 Principles and foundations of epidemiology and neurology research

1. Epidemiology for the clinical neurologist

2. Population neuroscience

3. Advanced epidemiological analytical methods

4. Basics of neuroanatomy and neurophysiology     C.K. Barha, L.S. Nagamatsu and T. Liu-Ambrose

5. Population imaging in neuroepidemiology

6. Use of “omics” technologies to dissect neurological disease

7. Neuropsychological assessment

SECTION 2 Epidemiology of disorders primarily affecting the nervous system

8. Dementias

9. Epidemiology of alphasynucleinopathies from Parkinson disease to dementia with Lewy bodies

10. Epidemiology of epilepsy

11. The epidemiology of multiple sclerosis: insights to a causal cascade

12. Neuroepidemiology of traumatic brain injury

13. The epidemiology of amyotrophic lateral sclerosis

14. Cerebrovascular disease

15. Peripheral neuropathies

16. Migraine

SECTION 3 Neurocognitive consequences of cancer and treatment-related neurocognitive dysfunction in adult-onset cancer patients and survivors

17. Neuroepidemiology of cancer and treatment-related neurocognitive dysfunction in adult-onset cancer patients and survivors

18. Sickle cell disease