Trafficking of GPCRs

G protein-coupled receptors (GPCRs) constitute the largest superfamily of cell surface receptors that regulate a variety of cell functions. Over the past few decades great progress has been made in defining the roles of intracellular trafficking in controlling the functionality of the receptors as well as in the development of various human diseases. This volume of Progress in Molecular Biology and Translational Science reviews the recent understanding of GPCR trafficking regulators and molecular mechanisms.

1. Arrestins: Critical Players in Trafficking of Many GPCRs
   Vsevolod V. Gurevich and Eugenia V. Gurevich
2. Regulation of GPCR Trafficking by Ubiquitin
   Justine E. Kennedy and Adriano Marchese
3. Rhodopsin Trafficking and Mistrafficking: Signals, Molecular Components and Mechanisms
   Ina Nemet, Philip Ropelewski and Yoshikazu Imanishi
4. Intracellular Trafficking of Neuropeptide Y Receptors
   Karin Mörl and Annette G. Beck-Sickinger
5. Insights into Serotonin Receptor Trafficking: Cell Membrane Targeting and Internalization
   Michèle Darmon, Sana Al Awabdh , Michel-Boris Emerit  and Justine Masson 
6. Calcium-Sensing Receptor: Trafficking, Endocytosis, Recycling and Importance of    Interacting Proteins
   Kausik Ray
7. Trafficking of β Adrenergic Receptors: Implications in Intracellular Receptor Signaling
   Qin Fu and Yang K. Xiang
8. Post-endocytic sorting of Adrenergic and Opioid Receptors: New Mechanisms and Functions.
   Shanna L. Bowman and Manojkumar A. Puthenveedu
9. α2 Adrenergic Receptor Trafficking as a Therapeutic Target in Antidepressant Drug Action
   Christopher Cottingham, Craig J. Ferryman and Qin Wang
10. Regulation of α2B-Adrenerigc Receptor Export Trafficking by Specific Motifs
    Guangyu Wu, Jason E. Davis and Maoxiang Zhang
11. Temperature-Sensitive Intracellular Traffic of Α2c-Adrenergic Receptor
    Catalin M. Filipeanu
12. N-Terminal Signal Peptides of G Protein-Coupled Receptors: Significance for Receptor Biosynthesis, Trafficking and Signal Transduction
    Claudia Rutz, Wolfgang Klein and Ralf Schülein
13. Regulation of GPCR Anterograde Trafficking by Molecular Chaperones and Motifs 
    Brent Young, Jaime Wertman and Denis J. Dupré