Developing Costimulatory Molecules for Immunotherapy of Diseases

Developing Costimulatory Molecules for Immunotherapy of Diseases highlights the novel concept of reverse costimulation and how it can be effectively exploited to develop immunotherapy using either humanized antibodies against CD80, CD86, and other costimulatory molecules or CD28 fusinogenic proteins in the treatment of diseases, including allergies, asthma, rheumatoid arthritis, multiple sclerosis, lupus nephritis, severe psoriasis, vulgaris tuberculosis, thopoid, transplantation therapeutic, cancer, and inflammation.

The text aims to provide the latest information on the complex roles and interactions within the CD28 and B7 costimulatory families, with the hope that targeting these families will yield new therapies for the treatment of inflammation, autoimmunity, transplantation, cancer, and other infectious diseases.

Highlights the novel concept of reverse costimulation and how it can be effectively exploited to develop immunotherapyProvides the latest information on the complex roles and interactions within the CD28 and B7 costimulatory familiesTargets new therapies for the treatment of inflammation, autoimmunity, transplantation, cancer, and other infectious diseases

Chapter 1: Introduction to costimulation and costimulatory molecules
Chapter 2. Concept of reverse costimulation and its role in diseases
Chapter 3. Costimulation immunotherapy in infectious diseases
Chapter 4. Costimulation immunotherapy in allergies and asthma
Chapter 5. Costimulation immunotherapy in lymphomas and cancer
Chapter 6. T cell costimulation and its applications in diseases