Negative Affective States and Cognitive Impairments in Nicotine Dependence

Negative Affective States and Cognitive Impairments in Nicotine Dependence is the only book of its kind that addresses nicotine use and abuse in the context of negative reinforcement mechanisms. Written and edited by leading investigators in addiction, affective, genetic, and cognitive research, it provides researchers and advanced students with an overview of the clinical bases of these effects, allowing them to fully understand the various underlying dysfunctions that drive nicotine use in different individuals. In addition, this book examines animal models that researchers have utilized to investigate the biological bases of these dysfunctions.

The combination of clinical and preclinical approaches to understanding nicotine dependence makes this book an invaluable resource for researchers and practitioners seeking to develop targeted treatments aimed at ameliorating symptoms of nicotine dependence, as well as identifying premorbid differences in affective or cognitive function.

Provides a unique perspective on nicotine dependence that emphasizes negative reinforcement rather than positive reinforcementExamines psychiatric comorbidities and alleviation of withdrawal states as motivation for continued tobacco useIncludes both clinical and preclinical perspectivesIncludes genetic and multi-neurotransmitter perspectives on nicotine use and withdrawalEmphasizes heterogeneity of underlying reasons for smoking, the need for multiple animal models to understand this heterogeneity, and the expectation of heterogeneous responses to potential treatments, underscoring the need for personalized therapeutics

1. Overview of Nicotine Withdrawal and Negative Reinforcement (Preclinical). Olivier George and George F. Koob. 2. Nicotine withdrawal and attentional deficit studies across species: Conflation with attentional dysfunction in psychiatric patients. Jordy van Enkhuizen and Jared W. Young. 3. Preclinical models of nicotine withdrawal: targeting impaired cognition. Mohammed Shoaib and F. Scott Hall. 4. Genetic, developmental, and receptor level influences on nicotine withdrawal-associated deficits in learning. Munir G. Kutlu, Erica Holliday and Thomas J. Gould. 5. Enhanced tobacco use vulnerability in adolescents, females and persons with diabetes. Joseph A Pipkin, Tiahna Ontiveros and Laura E. O’Dell. 6. Detrimental effects of prenatal exposure to tobacco smoke and nicotine. Tomasz Schneider. 7. Contribution of mouse genetic models to our understanding of nicotine dependence. F. Scott Hall, Yosefu Arime, Yasir Saber and Ichiro Sora. 8. Transmitters and receptors in nicotine withdrawal syndrome. David H. Malin, Andrea N. Anderson and Pilar Goyarzu. 9. The cannabinoid system in nicotine dependence and withdrawal. Meghan E. Mcilwain, Arpi Minassian, and William Perry. 10. Critical role for brain stress systems in the negative affective state associated with nicotine withdrawal. Xiaoli Zi, Dawn M. Bruijnzeel, and Adriaan W. Bruijnzeel. 11. The habenula-interpeduncular pathway and nicotine withdrawal. Christie D. Fowler. 12. A Clinical overview of nicotine dependence and withdrawal. Mai Frandsen, Mona Thorpe, Saul Shiffman, and Stuart G. Ferguson. 13. Epidemiologic research on the relationship of nicotine dependence to psychiatric and substance use disorders. Kate S. Segal, Hannah Esan, Alyssa R. Burns, and Andrea H. Weinberger. 14. Nicotine and tobacco smoking and withdrawal in schizophrenia. Karolina Kozak and Tony P. George. 15. Emergent cognitive impairment during early nicotine withdrawal. Randi M. Schuster and A. Eden Evins. 16. Nicotine and posttraumatic Stress Disorder. Dean T. Acheson and Daniel E. Glenn. 17. Nicotine withdrawal and depression: Clinical studies – a four-factor model for more accurate characterization. David G. Gilbert and Michel L. Pergadia. 18. Neuroimaging insights into the multifaceted nature of the nicotine withdrawal syndrome. Matthew T. Sutherland, Julio A. Yanes, and Elliot A. Stein.