Emerging Trends in Computational Biology, Bioinformatics, and Systems Biology: Algorithms and Software Tools

Emerging Trends in Computational Biology, Bioinformatics, and Systems Biology discusses the latest developments in all aspects of computational biology, bioinformatics, and systems biology and the application of data-analytics and algorithms, mathematical modeling, and simu- lation techniques.

• Discusses the development and application of data-analytical and theoretical methods, mathematical modeling, and computational simulation techniques to the study of biological and behavioral systems, including applications in cancer research, computational intelligence and drug design, high-performance computing, and biology, as well as cloud and grid computing for the storage and access of big data sets.

• Presents a systematic approach for storing, retrieving, organizing, and analyzing biological data using software tools with applications to general principles of DNA/RNA structure, bioinformatics and applications, genomes, protein structure, and modeling and classification, as well as microarray analysis.

• Provides a systems biology perspective, including general guidelines and techniques for obtaining, integrating, and analyzing complex data sets from multiple experimental sources using computational tools and software. Topics covered include phenomics, genomics, epigenomics/epigenetics, metabolomics, cell cycle and checkpoint control, and systems biology and vaccination research.

• Explains how to effectively harness the power of Big Data tools when data sets are so large and complex that it is difficult to process them using conventional database management systems or traditional data processing applications.

Discusses the development and application of data-analytical and theoretical methods, mathematical modeling and computational simulation techniques to the study of biological and behavioral systems.Presents a systematic approach for storing, retrieving, organizing and analyzing biological data using software tools with applications. Provides a systems biology perspective including general guidelines and techniques for obtaining, integrating and analyzing complex data sets from multiple experimental sources using computational tools and software.

CHAPTER 1 Supervised Learning with the Artificial Neural Networks Algorithm for Modeling Immune Cell Differentiation

CHAPTER 2 Accelerating Techniques for Particle Filter

Implementations on FPGA

CHAPTER 3 Biological Study on Pulsatile Flow of Herschel-Bulkley Fluid in Tapered Blood Vessels

CHAPTER 4 Hierarchical k-Means: A Hybrid Clustering Algorithm and its Application to Study Gene Expression in Lung Adenocarcinoma

CHAPTER 5 Molecular Classification of N-Aryloxazolidinone-5- carboxamides as Human Immunodeficiency Virus Protease Inhibitors

CHAPTER 6 Review of Recent Protein-Protein Interaction Techniques

CHAPTER 7 Genetic Regulatory Networks: Focus on Attractors Of Their Dynamics

CHAPTER 8 Biomechanical Evaluation for Bone Allograft in Treating the Femoral Head Necrosis: Thorough Debridement or Not?

CHAPTER 9 Diels-Alderase Catalyzing the Cyclization Step In the Biosynthesis of Spinosyn A: Reality or Fantasy?

CHAPTER 10 CLAST: Clustering Biological Sequences

CHAPTER 11 Computational Platform for Integration and Analysis of MicroRNA Annotation

CHAPTER 12 Feature Selection and Analysis of Gene Expression Data Using Low-Dimensional Linear Programming

CHAPTER 13 The Big ORF Theory: Algorithmic, Computational, and Approximation Approaches to Open Reading Frames in Short- and Medium-Length dsDNA Sequences

CHAPTER 14 Intentionally Linked Entities: A Detailed Look At a Database System for Health Care Informatics

CHAPTER 15 Region Growing in Nonpictorial Data for Organ-Specific Toxicity Prediction

CHAPTER 16 Contribution of Noise Reduction Algorithms: Perception Versus Localization Simulation in the Case of Binaural Cochlear Implant (BCI) Coding

CHAPTER 17 Lowering the Fall Rate of the Elderly From Wheelchairs

CHAPTER 18 Occipital and Left Temporal EEG Correlates of Phenomenal Consciousness

CHAPTER 19 Chaotic Dynamical States in the Izhikevich Neuron Model

CHAPTER 20 Analogy, Mind, and Life

CHAPTER 21 Copy Number Networks to Guide Combinatorial Therapy of Cancer and Proliferative Disorders

CHAPTER 22 DNA Double-Strand Break–Based Nonmonotonic Logic

CHAPTER 23 An Updated Covariance Model for Rapid Annotation of Noncoding RNA

CHAPTER 24 SMIR: A Web Server to Predict Residues Involved in the Protein Folding Core

CHAPTER 25 Predicting Extinction of Biological Systems with Competition

CHAPTER 26 Methodologies for the Diagnosis of the Main Behavioral Syndromes for Parkinson’s Disease with Bayesian Belief Networks

CHAPTER 27 Practical Considerations in Virtual Screening and Molecular Docking

CHAPTER 28 Knowledge Discovery in Proteomic Mass Spectrometry Data

CHAPTER 29 A Comparative Analysis of Read Mapping and Indel Calling Pipelines for Next-Generation Sequencing Data

CHAPTER 30 Two-Stage Evolutionary Quantification of In Vivo MRS Metabolites

CHAPTER 31 Keratoconus Disease and Three-Dimensional Simulation of the Cornea Throughout the Process of Cross-Linking Treatment

CHAPTER 32 Emerging Business Intelligence Framework for a Clinical Laboratory Through Big Data Analytics

CHAPTER 33 A Codon Frequency Obfuscation Heuristic for Raw Genomic Data Privacy