The Molecular Basis of Viral Infection

Virology is in a sense both one of the most important precursors and one of the most significant beneficiaries of structural and cellular molecular biology. Numerous breakthroughs in our understanding of the molecular interactions of viruses with host cells are ready for translation into medically important applications such as the prevention and treatment of viral infections. This book collects a wide variety of examples of frontline research into molecular aspects of viral infections from virological, immunological, cell- and molecular-biological, structural, and theoretical perspectives.

Contributors are world leaders in their fields of study and represent prestigious academic and research institutionsReview articles vary vastly in scope: some focus on a narrowly defined scientific problem of one particular virus with careful introduction for the non-specialist; others are essays in general and comparative virology with forays into specific viral species or moleculesThe different perspectives complement each other and collectively the contributions provide an impression of the fast-moving frontlines of virology while showing how the problems have evolvedStructural data are presented through high-quality illustrations

1. Unity in Diversity: Shared Mechanism of Entry Among Paramyxoviruses
   Jean-Louis Palgen, Eric M. Jurgens, Anne Moscona, Matteo Porotto and Laura M. Palermo
2. Alphavirus Entry into Host Cells
   Ricardo Vancini, Raquel Hernandez and Dennis Brown
3. The Mechanism of HCV Entry into Host Cells
   Florian Douam, Dimitri Lavillette and François-Loïc Cosset
4. The Evolution of HIV Interactions with Coreceptors and Mannose C-type lectin Receptors
   Marie Borggren and Marianne Jansson
5. A Game of Numbers: The Stoichiometry of Antibody-mediated Neutralization of Flavivirus Infection
   Theodore C. Pierson and Michael S. Diamond
6. TRIM21-dependent Intracellular Antibody Neutralization of Virus Infection
   William A. McEwan and Leo C. James
7. Picornavirus-host Interactions to Construct Viral Secretory Membranes
   Alexander L. Greninger
8. Retroviral Factors Promoting Infectivity
   Emilia Cristiana Cuccurullo, Chiara Valentini and Massimo Pizzato
9. The Cytoplasmic Tail of Retroviral Envelope Glycoproteins
   Philip R. Tedbury and Eric O. Freed
10. Molecular Determinants of the Ratio of Inert to Infectious Virus Particles
    P.J. Klasse
11. The Role of Chance in Primate Lentiviral infectivity: From Protomer to Host Organism
    Roland R. Regoes and Carsten Magnus
12. Virus-encoded 7 Transmembrane Receptors
    Ann-Sofie Mølleskov-Jensen, Martha Trindade Oliveira, Helen Elizabeth Farrell and Nick Davis-Poynter
13. EBV, the Human Host and the 7TM Receptors: Defense or Offense?
    Kristine Niss Arfelt, Suzan Fares and Mette M. Rosenkilde