Structure to Function of G Protein-Gated Inwardly Rectifying (GIRK) Channels

This volume in the International Review of Neurobiology series is a comprehensive overview of the state-of-the-art research into GIRK Potassium Channels. It reviews current knowledge and understanding and provides a starting point for researchers and practitioners entering the field.

1. Unifying Mechanism of Controlling Kir3 Channel Activity by G Proteins and Phosphoinositides

Diomedes E. Logothetis, Rahul Mahajan, Scott K. Adney, Junghoon Ha, Takeharu Kawano, Xuan-Yu Meng and Meng Cui

2. The Roles of Gβγ and Gα in Gating and Regulation of GIRK Channels

Nathan Dascal and Uri Kahanovitch

3. RGS Redundancy and Implications in GPCR-GIRK Signaling

Craig A. Doupnik

4. Structural Insights into GIRK Channel Function

Ian W. Glaaser and Paul A. Slesinger

5. Localization and Targeting of Girk Channels in Mammalian Central Neurons

Rafael Luján and Carolina Aguado

6. GIRK Channel Plasticity and Implications for Drug Addiction

Ezequiel Marron Fernandez de Velasco, Nora McCall and Kevin Wickman

7. GIRK Channels: a Potential Link Between Learning and Addiction

Megan E. Tipps and Kari J. Buck

8. Behavioral and Genetic Evidence for GIRK Channels in the CNS: Role in Physiology, Pathophysiology, and Drug Addiction Jody Mayfield, Yuri A. Blednov and R. Adron Harris