Systems Neuroscience in Depression

Systems Neuroscience in Depression provides a comprehensive overview of the normal and depressed brain processes as studied from a systems neuroscience perspective. Systems neuroscience uses a wide variety of approaches to study how networks of neurons form the bases of higher brain function. A broad overview is discussed starting with a background from neurodevelopment and neural understanding as well as novel treatment approaches for depression. This book covers basic developmental aspects and depressive psychopathology, as well as the basic scientific background from animal models and experimental research. Current advances in systems neuroscience are highlighted in studies from child and adolescent psychiatry. Integrated approaches are presented with regards to genetics, neuroimaging and neuroinflammation as well as neuroendocrinology. The field of systems and network neuroscience is evolving rapidly and this book provides a greatly needed resource for researchers and practitioners in systems neuroscience and psychiatry.

Knowledge covering the whole life span from early to later lifeComprehensively written chapters developing from molecules via epigenetics and neural circuits to clinical neuroscienceUnderstanding the neurobiology of major depressive disorderIntegrating stress and environmental factors with molecular underpinningsMore than 25 illustrations and tables

Developmental Aspects 1. A multilevel developmental psychopathology systems perspective on depression 2. Early Life Adversity and Risk for Depression: Alterations in Cortisol and Brain Structure and Function as Mediating Mechanisms

Experimental System Neuroscience 3. Novel targets in the glutamate and nitric oxide neurotransmitter systems for the treatment of depression 4. Anti-inflammatory and immune-modulatory therapeutic approaches in depression 5. Molecular Mechanisms of Depression

System Neuroscience 6. Epigenetics Mechanisms in Depression 7. Identifying Large scale neural networks using fMRI 8. Imaging functional systems in depression 9. Integrating the Stress Systems and Neuroimaging in Depression 10. Depression in children and adolescents 11. Systems Neuroscience in Late-Life Depression 12. Arousal regulation in affective disorders