Human Vaccines: Emerging Technologies in Design and Development

Human Vaccines: Emerging Technologies in Design and Development discusses the advances in molecular biology, biophysics, and informatics—among other disciplines—that have provided scientists with the tools to create new vaccines against emerging and re-emerging pathogens.

For example, the virus-like particle technologies that led to licensing of highly efficacious HPV vaccines have only come into full realization in the last 10 years. Their success has, in turn, accelerated the pace with which nanoparticle vaccines are being developed

Given the rapidity with which the field is changing and the absence of any text documenting this change, there is a need for a resource that surveys these new vaccine technologies, assesses their potential, and describes their applications. This book provides that resource and complements traditional vaccinology books, but also serves as an excellent standalone for researchers and students with basic knowledge in immunology.

Introduces new topics in vaccine immunology in the context vaccine design and productionConsolidates the growing body of knowledge on new vaccine technologies that have only emerged in the past 2 – 3 decadesReviews the currently licensed vaccines that have utilized leading-edge technologies and how this has translated into improved efficacy and safetyProvides a broad overview of innovative vaccine technologies, including immunological aspects

Part I: Designing Vaccines From a New Starting Point

Chapter 1. Broadly Neutralizing Antibodies

Part II: Pathogen Free Vaccines

Chapter 2. Replication-Competent Viral Vectors for Vaccine Delivery

Chapter 3. Reverse Vaccinology: Exploiting Genomes for Vaccine Design

Chapter 4. Virus-Like Particle and Nanoparticle Vaccines

Part III: Immune Monitoring

Chapter 5. Systems Vaccinology

Chapter 6. Immunogenetics and Vaccination

Part IV: Advanced Vaccine Development

Chapter 7. Methodical Considerations

Chapter 8. Vaccine Development in Special Populations