Chemical Modulators of Protein Misfolding and Neurodegenerative Disease

This book is a neurochemistry-based companion for Protein Misfolding and Neurodegenerative Diseases: Molecular Targets, an Elsevier title by the same author publishing in December 2014. While the first book focuses on biology and molecular targets, this companion book describes how these targets are regulated by small molecules and disease-modifying compounds. The book begins with a brief introduction to how key proteins become dysfunctional, and each subsequent chapter describes major disease mechanisms in Alzheimer’s and other tauopathies. Properties and development status of these molecular targets and disease mechanisms are thoroughly described, as are small molecule effectors of autophagy and dis-aggregating agents.

Written to provide comprehensive coverage of neurodegenerative disease-modifying compoundsProvides discipline-specific chapters that cover medicinal chemistry and clinical applicationsProvides an overview of more than 200 chemical classes and lead compounds, acting on selected molecular targets that are of relevance to any neurodegenerative disorderCoverage of misfolding diseases, chaperone proteins, ubiquitination and autophagy/oncology makes this book suitable for structural neurochemists, chemists, biologists, non-CNS scientists, and scientists interested in drug discovery

Chapter 1 Chemical modulators of protein misfolding, neurodegeneration and tau: What’s not covered next
Chapter 2 Targeting the protein quality control (PQC) machinery: Chaperones & Co...
Chapter 3 Targeting proteasomal degradation of soluble, misfolded proteins: Ubi major
Chapter 4 Targeting unselective autophagy of cellular aggregates: A shotgun approach
Chapter 5 Targeting selective autophagy of insoluble protein aggregates: The sniper’s philosophy
Chapter 6 Targeting assembly and disassembly of protein aggregates: A raggle-taggle bunch with high hopes