The Cerebral Cortex in Neurodegenerative and Neuropsychiatric Disorders: Experimental Approaches to Clinical Issues

The Cerebral Cortex in Neurodegenerative and Neuropsychiatric Disorders: Experimental Approaches to Clinical Issues focuses on how pre-clinical investigations are addressing the clinical issues surrounding the involvement of the cerebral cortex in selected conditions of the nervous system, including Alzheimer’s Disease, Parkinson’s, addiction, and cardiovascular dysregulation.

Each chapter is written by an expert in his/her field who provides a comprehensive review of the clinical manifestations of cortical involvement and experimental techniques currently available to tackle cortical issues in disease. Thus, this present title provides a link between cortical clinical problems and investigational approaches to help foster future research with high translational value.

Offers a comprehensive overview on the best available in vivo and in vitro models to study cortical involvementPresents models and specific techniques that help to guide investigators in their choices on how to address research questions experimentallyProvides expert commentary and a perspective on future trends at the end of each chapter Addresses translational advances and promising therapeutic optionsIncludes references to key articles for additional detailed study

Part I. Introductory Chapters

Chapter 1. Anatomy of the Cerebral Cortex

Chapter 2. Cortical Plasticity in Response to Injury and Disease

Chapter 3. Imaging Approaches to Cerebral Cortex Pathology

Part II. The Cerebral Cortex in Neurodegenerative Disorders

Chapter 4. Alzheimer’s Disease

Chapter 5. Vascular Dementia

Chapter 6. Frontotemporal Dementia

Chapter 7. Parkinson’s Disease and the Cerebral Cortex

Chapter 8. Huntington Disease

Chapter 9. Cortical Manifestations in Amyotrophic Lateral Sclerosis

Chapter 10. Cortical Involvement in Multiple Sclerosis

Part III. The Cerebral Cortex in Neuropsychiatric Disorders

Chapter 11. Prefrontal Cortical Abnormalities in Cognitive Deficits of Schizophrenia

Chapter 12. Role of the Prefrontal Cortex in Addictive Disorders