Insights to Neuroimmune Biology

Insights to Neuroimmune Biology, Second Edition discusses the systemic regulatory network, coordination, organization, and interpretation of the rapidly accumulating knowledge on the topic of neuroimmune biology, with an ultimate goal of helping readers understand the function of higher organisms, including man, in their entire complexity.

This publication provides assessments and interpretations of accumulated experimental evidence, enabling the scientific community to keep abreast of essential advancements of existing knowledge as we search for greater understanding of the biology of higher organisms.

Provides information on the importance and applicability of the field of neuroimmunology Describes subjects that have shown significant recent developmentsIntroduces a whole new dimension to neuroimmunology by discussing Epigenetic ImmunoregulationInvestigates the mechanisms and functions of the Neuroimmune Regulatory SupersystemPromotes translational research in the field of neuroimmune biologyCovers challenges, such as dealing with problems of e.g., hypothalamic regulation of immune functions, interrelationships of stress and disease, epigenetic immunoregulation, neuroprotection, and neuroimmune regulation in pregnancy.

• List of Contributors
• Foreword
• Preface
• Part 1: Introduction: Neuroimmune Regulation in Health and Disease
  • Chapter 1: Neuroimmune Regulation in Health and Disease
    • Abstract
    • 1. Introduction
    • 2. Disease
    • 3. Discussion
    • 4. Conclusions
  • Chapter 2: The Neuroimmune Supersystem
    • Abstract
    • 1. Introduction
    • 2. The neuroimmune supersystem
    • 3. Immunocompetence
    • 4. Growth signaling in the IS
    • 5. Immune neuroendocrine feedback signals
    • 6. Homeostasis, the immune-neuroendocrine circuitry
    • 7. Acute illness
    • 8. Healing
    • 9. Conclusions: the biological significance of NISS
• Part 2: Hypothalamic Immunoregulation
  • Chapter 3: Multifactorial Regulation of GLH Hormones
    • Abstract
    • 1. Immunoregulation by the pituitary gland
    • 2. Immunoregulation by growth and lactogenic hormones
    • 3. Dopamine in neuroimmune biology
    • 4. Immunoregulation by dopamine
    • 5. Oxytocin and ghrelin in immunity
    • 6. Conclusions
  • Chapter 4: An Update on Neural Regulators of the Hypothalamic-Pituitary-Adrenal Axis
    • Abstract
    • 1. Corticotropin-releasing hormone
    • 2. Neuropeptide regulators of the HPA axis
    • 3. CRH and the CNS
    • 4. CRH-Receptors 1 and 2 (CHR1, 2) and UCN Receptors
    • 5. Hormonal immunoregulation and the HPA axis
    • 6. Discussion
  • Chapter 5: Arginine Vasopressin: An Immunoregulatory Hormone
    • Abstract
    • 1. Introduction
    • 2. Conclusions
  • Chapter 6: Integration and Coordination of Bodily Functions by NISS
    • Abstract
    • 1. Introduction
• Part 3: Neuropeptides as Immunoregulators
  • Chapter 7: Neuropeptides in Immunoregulation
    • The Discovery of Neurogenic Inflammation
    • Papers on Neurogenic Inflammation
    • Neuropeptides as Immunoregulators
    • Current Papers on Neuroimmune Regulation by Neuropeptides
• Part 4: Neuroimmune Pathology
  • Chapter 8: Vasopressin, the Acute Phase Response and Healing
    • Abstract
    • 1. Introduction
    • 2. Conclusions
  • Chapter 9: Chronic Stress and Disease
    • Abstract
    • 1. Introduction
    • 2. Forms of chronic stress
    • 3. Chronic stress and disease
    • 4. Mechanisms linking chronic stress and disease
    • 5. Summary and conclusions
• Part 5: Epigenetic Immunoregulation
  • Chapter 10: Biologically Controlled Mutations are Right for Evolution
    • Abstract
    • 1. Introduction
    • 2. Stress and epigenetic programming
  • Chapter 11: Prevention of Alcohol-Induced Inflammation of Murine Small Intestine by MicroRNA-155 Deficiency
    • Abstract
    • 1. Alcohol-induced inflammation in proximal small intestine - general considerations (Figure 11.1)
    • 2. Differences between acute and chronic drinking on barrier function and serum-endotoxin levels (Table 11.1)
    • 3. Differences between acute and chronic drinking on the intestinal inflammatory changes (Table 11.1)
    • 4. miRNAs regulating intestinal functions
    • 5. miRNA-155 regulating intestinal functions
    • 6. miRNA-155 deficiency protects chronic alcohol-fed mice from serum-endotoxin changes (Table 11.1)
    • 7. miRNA-155 deficiency protects chronic alcohol-fed mice from inflammatory changes in the small intestine (Table 11.1)
    • 8. miRNA-155 deficiency protects chronic alcohol-fed mice from inflammatory changes in the cerebellum (Table 11.2)
    • 9. Conclusions
• Part 6: Neuroprotection
  • Chapter 12: Neuroprotection
    • Abstract
    • 1. Introduction
    • 2. Gut microbiota and the brain
    • 3. Clinical relevance of neuroimmune regulation
    • 4. Conclusions
• Index