The Choroid Plexus and Cerebrospinal Fluid: Emerging Roles in CNS Development, Maintenance, and Disease Progression

The Choroid Plexus and Cerebrospinal Fluid: Emerging Roles in CNS Development, Maintenance, and Disease Progression combines new and established work to allow for cross-disciplinary discussion and showcase newfound excitement surrounding the choroid plexus and cerebrospinal fluid (CSF). This book is of great utility to neuroscientists interested in biological questions about cancer, multiple sclerosis, Alzheimer’s, choroid plexus, or CSF research, and especially for researchers looking to expand their research into later stages of their disease of interest, such as metastasis. No other resource is currently available which addresses these issues in this fashion. The focus on the choroid plexus provides a practical resource on modeling clinical issues influenced by this brain region for researchers from students to principal investigators.

Presents recent progress made in the research of choroid plexus and cerebrospinal fluid across multi-disciplinary fields, including neuroscience, cancer biology, and immunologyIncludes numerous illustrations of light, fluorescent, and electron micrographsProvides data analysis boxes in each chapter to help with data interpretation and offer guidelines on how best to represent resultsIncludes chapters written by prominent researchers in the field

1. Introduction to the Ventricular System and Choroid Plexus     Tatsuhiro Fujii, Joshua Youssefzadeh, Michael Novel and Josh Neman

2. Development of brain ventricles and choroid plexus     Ellen M. Carpenter

3. Choroid plexus: Structure and Function     Florence M. Hofman and Thomas C. Chen

4. Towards an artificial choroid plexus, concept and clinical implications     Thomas Brinker and John Morrison

5. Choroid Plexus Tumors     Sean A. Grimm and Marc C. Chamberlain

6. Role of Blood Brain Barrier, Choroid Plexus, and Cerebral Spinal Fluid in Extravasation and Colonization of Brain Metastases     Cecilia Choy and Josh Neman

7. The Role of the Choroid Plexus in the Pathogenesis of Multiple Sclerosis     Vahan Martirosian, Alex Julian and Josh Neman

8. The Choroid Plexus and Cerebrospinal Fluid system: roles in neurodegenerative diseases     Jérôme Badaut and Jean-François Ghersi-Egea

9. Delivery Considerations for Targeting the Choroid Plexus-Cerebrospinal Fluid Route     Thomas C. Chen

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