Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes

Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes is the first book to highlight the multi-disciplinary nature of this specialized field and the importance of collaboration between medical and engineering laboratories in the development of tissue-oriented products for tissue engineering and regenerative medicine (TERM) strategies.

Beginning with a foundation in developmental biology, the book explores physiology, pathology, and surgical reconstruction, providing guidance on biological approaches that enhances tendon regeneration practices.

Contributions from scientists, clinicians, and engineers who are the leading figures in their respective fields present recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field.

Provides an overview of tendon biology, disease, and tissue engineering approachesPresents modern, alternative approaches to developing functional tissue solutions discussedIncludes valuable information for those interested in tissue engineering, tissue regeneration, tissue physiology, and regenerative medicineExplores physiology, pathology, and surgical reconstruction, building a natural progression that enhances tendon regeneration practicesCovers recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field

Preface Manuela E. Gomes, Marcia T. Rodrigues, Rui L. Reis

1. Tendon Physiology and Mechanical Behavior: Structure-Function Relationships 2. Tendon Resident Cells – Function and Features 3. Mechanobiology of Tendons

Section II – Pathologies and repair of tendons 4. Tendinopathies (I): Understanding Epidemiology, Pathology,  Healing and Treatment 5. Tendinopathies (II): Etiology, Pathology, and Healing of Tendon Injury and Disease

Section III- Tendon Regenerative Medicine approaches 6. Cell Based Approaches for Tendon Regeneration 7. GF Approaches in Tendon Stimulation

Section IV – Scaffolds-Based Approaches 8. Scaffold-Based Approaches (I): Engineering anisotropic 2D and 3D structures for tendon repair and regeneration 9. Scaffold-Based Approaches (II): Biological and synthetic based scaffolds for tendon regeneration

Section V – Tendon Tissue Engineering 10. Tendon TE: Hierarchical and Biomimetic Structures to Support the Regeneration of Tendon Tissues 11. Tendon TE: Multifactoral Tendon Tissue Engineering Strategies 12. Tendon TE: Combined Tissue Engineering Approach for the Regeneration of Tendons 13. Tendon TE: Biomaterial scaffolds for tendon tissue engineering 14. Pre-Clinical models for Tendon Translational Therapies 15. Scaffold design for integrative tendon-bone repair