Molecular Nutrition and Diabetes: A Volume in the Molecular Nutrition Series

Molecular Nutrition and Diabetes: A Volume in the Molecular Nutrition Series focuses on diabetes as a nutritional problem and its important metabolic consequences. Fuel metabolism and dietary supply all influence the outcome of diabetes, but understanding the pathogenesis of the diabetic process is a prelude to better nutritional control.

Part One of the book provides general coverage of nutrition and diabetes in terms of dietary patterns, insulin resistance, and the glucose-insulin axis, while Part Two presents the molecular biology of diabetes and focuses on areas such as oxidative stress, mitochondrial function, insulin resistance, high-fat diets, nutriceuticals, and lipid accumulation. Final sections explore the genetic machinery behind diabetes and diabetic metabolism, including signaling pathways, gene expression, genome-wide association studies, and specific gene expression. While the main focus of each chapter is the basic and clinical research on diabetes as a nutritional problem, all chapters also end with a translational section on the implications for the nutritional control of diabetes.

Offers updated information and a perspective on important future developments to different professionals involved in the basic and clinical research on all major nutritional aspects of diabetes mellitusExplores how nutritional factors are involved in the pathogenesis of both type1 and type2 diabetes and their complicationsInvestigates the molecular and genetic bases of diabetes and diabetic metabolism through the lens of a rapidly evolving field of molecular nutrition

Section 1: General and Introductory Aspects

1. Nutrition and diabetes: general aspects

  Ana M. Wägner, Julia Charlotte Wiebe, Rosa M. Sánchez-Hernández and Lidia García-Pérez

2. Dietary patterns and insulin resistance

  Marcio A. Torsoni, Adriana Souza Torsoni and Marciane Milanski

3. Beta cell metabolism, insulin production and secretion; metabolic failure resulting in diabetes

  Younan Chen, Vinicius Fernandes Cruzat and Philip Newsholme

4. Diet-gene interactions in the development of diabetes

  Jose M. Ordovas

5. Pathogenesis of type 1 diabetes: role of dietary factors

  Julie Christine Antvorskov, Karsten Buschard and Knud Josefsen

Section 2: Molecular biology of the cell

6. Oxidative stress in diabetes mellitus: molecular aspects: implications for the diet

  Lu Cai

7. Muscle protein in type 2 diabetes: Molecular aspects

  Antonio Zorzano

8. Mechanisms whereby wholegrain cereals modulate the prevention of type-2 diabetes

  Knud Erik Bach Knudsen, Kjeld Hermansen, Mette Skou Hedemann and Merete Lindberg Hartvigsen

9. Peroxisome proliferator activated receptors -PPARs - in glucose control

  Massimo Collino and Fausto Chiazza

10. High-fat diets and beta-cell dysfunction: molecular aspects

  Carla B. Collares-Buzato

11. Native fruits, anthocyanins in nutraceuticals and the insulin receptor/insulin receptor substrate-1/Akt/ forkhead box protein pathway

  N.R.V. Dragano and Anne y Castro Marques

12. Influence of dietary factors on gut microbiota: role on insulin resistance and diabetes mellitus

  Gemma Xifra Villarroya, Eduardo Esteve and J.M Fernandez-Real

13. Molecular aspects of Glucose regulation of pancreatic beta-cells

  Rosa Gasa, Ramon Gomis, Anna Novials and Joan-Marc Servitja

14. Metals and signalling in diabetes

  Lu Cai

15. Cocoa flavonoids and insulin signalling

  Sonia Ramos, M.A. Martin and Luis Goya

16. Dietary proanthocyanidin modulation of pancreatic beta-cells: molecular aspects

  Montserrat Pinent, Mayte Blay, Anna Ardevol and Noemi Gonzalez-Abuin

17. Dietary whey protein and Type 2 diabetes: molecular aspects

  Jaime Amaya-Farfan, Priscila Neder Morato, Carolina Soares Moura and Pablo Lollo

18. Dietary fatty acids and C-reactive proteins in diabetes

  Giovanni Annuzzi, Ettore Griffo, Giuseppina Costabile and Lutgarda Bozzetto

19. Alcoholic beverage and diabetes: cellular and molecular effects

  Suzanne de la Monte

Section 3: Genetic machinery and its function

20. Alleles and risk of diabetes

  Valeriya Lyssenko

21. Micro RNAs in diabetes

  Louise Torp Dalgaard, Sofia Anna Salö, Anja Elaine Sørensen and Julian Geiger

22. Diabetes mellitus and intestinal Niemann-Pick C1-Like1 gene expression

  W. A. Alrefai, Pooja Malhotra, Ravinder K. Gill and Pradeep K. Dudeja

23. Dietary long-chain omega-3 polyunsaturated fatty acids and inflammatory gene expression in type 2 diabetes

  Manohar Lal Garg

24. Polymorphisms, carbohydrates, fat and type 2 diabetes: the example of insulin receptor substrate 1 (IRS1)

  Jose Lopez-Miranda

25. Genetic basis linking variants for diabetes and obesity with breast cancer

  Vijay Kumar Kutala

26. Genetic determinants of pathways underlying 25(OH) vitamin D deficiency predisposing to type 1 and type 2 diabetes mellitus

  Dharambir K. Sanghera and Piers R. Blackett

27. NRF2-mediated gene regulation and glucose homeostasis

  Masayuki Yamamoto and Akira Uruno

28. Hepatic mitochondrial fatty acid oxidation and type 2 diabetes

  Abdelhak Mansouri, Wolfgang Langhans, Jean Girard and Carina Prip-Buus

29. The wnt signaling pathway and glucose homeostasis

  T. Jin