Translational Immunology: Mechanisms and Pharmacologic Approaches

Translational Immunology: Mechanisms and Pharmacologic Approaches highlights and summarizes the most important advances in human immunology, clinical translations, new tools to analyze therapeutic targets, and new pharmacological approaches for autoimmunity, inflammatory disorders, and cancer. The book is an essential resource for those seeking to understand the potential translational applications of burgeoning studies in human immunology, helping readers make sense of the existing and emerging scientific advances. The book grounds fundamental science in the translational realm, providing insights from world renowned researchers at the top of their game in their respective fields, in both industry and academic settings.

Readers will gain an understanding of the rationale and mechanisms underlying current and emerging pharmacologic approaches for interventional immunology, the gaps therein, and new ideas for better and safer therapeutic approaches, and physicians will glean information about pharmacological limitations in altering disease progression and complications. This reference on the translational realization of the burgeoning findings in immunology provides a go-to reference for experienced professional clinicians, researchers, industry scientists, and those seeking more information on the field.

Delivers comprehensive coverage of seminal human immunology discoveries and the resulting impact on therapeutic strategiesPresents potential novel targets and approaches for clinical applications in organ specific and systemic autoimmunity, transplant rejection, cancer, and vaccine developmentDiscusses lessons learned from successful and failed clinical trials with specific interventions, including pharmacological issues and limitations, and complications due to immunosuppressionProvides information on new strategies and outstanding issues that should be addressed in future research

Preface
 
Section A: Human Immunology
1. Systems Immunology
2. Primary Immunodeficiencies
3. Phenome-wide association study (PheWAS)
4. Gene Regulatory Network
5. TCR Repertoire Analysis
 
Section B: Current and Emerging Pharmacological Targets
6. TH17
7. TH9
8. TFH
9. Regulatory T cells
10. Regulatory B cells
 
Section C: New Approaches
11. Immune Tolerance Induction
12. Humanized Mouse Models
13. Patient Stratification and Biomarkers