Pyrantel Parasiticide Therapy in Humans and Domestic Animals

Pyrantel Parasiticide Therapy in Humans and Domestic Animals presents a single source history and reference on the parasiticide activity and pharmacology of the tetrahydropyrimidines and their salts in humans and domestic animals, also collating evidence that resistance to pyrantel has developed in human and domestic animal nematodes.

Other books of this nature have been compiled historically for specific anthelmintic compounds, but none has been written to date for the pyrantel family of drugs. Pyrantel, a nicotinic receptor agonist, has been used in domestic animal and human medicine since the 1970’s to control two important nematode groups, the hookworms and the roundworms.

Given the zoonotic potential of these parasites, pyrantel has served a dual role in helping to protect the health of both domestic animals and the public for more than 45 years.

Easy-to-use reference guide on the anthelmintic pyrantel for clinicians, parasitologists, and researchers in human and veterinary medicine Addresses current issues of resistance, along with combination uses against anthelmintic resistant parasites Presents useful, authoritative information (chemical, pharmaceutical, clinical, etc.) for the pyrantel family of compoundsIncludes a discussion on pyrantel’s potential role in combination therapies Provides cutting-edge material, and will be an evolving area of scientific discussion of treatment options in the future

Preface
Introduction
History of the Discovery and Chemistry of Pyrantel, Oxantel, and Morantel
Pharmacology and Anthelmintic Resistance
Safety of Pyrantel, Oxantel and Morantel
Formulations and Clinical Uses of Pyrimidine Compounds in Domestic Animals
Pyrantel in Human Anthelmintic Therapy
Unmet needs and Concluding Remarks