Brain Metastases from Primary Tumors, Volume 2: Epidemiology, Biology, and Therapy

Brain metastases are the most common malignant tumors of the central nervous system, yet their incidence appears to be increasing in spite of the advancement of cancer therapies. While much is known about primary cancers (including primary brain tumors), less work has been done to uncover the roots of metastatic disease. Brain Metastases from Primary Tumors fills that gap, serving as the first two-part reference to focus primarily on the link between primary cancers and brain metastases. This link is explored for the most common cancer types – lung, breast, and melanoma. Additionally, biological background as well as therapy for CNS metastases is addressed. Age- and gender-related trends are also discussed, as is the use of biomarkers for early detection.

The only comprehensive reference detailing the link between primary cancers and brain metastasesAids the target audience in determining the incidence of brain metastases in patients with a primary cancerProvides education about the potential use of biomarkers for early detection, diagnosis and prevention of the spread of primary cancer to the brainDocuments temporal and gender-related trends in brain metastases from other cancersEdited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage availableThe only comprehensive reference detailing the link between primary cancers and brain metastases

I.  GENERAL APPLICATIONS 1. Brain Metastasis from Solid Tumors 2. The Role of Surgical Resection for Metastatic Brain Tumors 3. Whole Brain Radiotherapy for Brain Metastases:  Is the Therapeutic Window Enlarging?

II. NON-SMALL CELL LUNG CANCER 4. Brain Metastasis in Patients with Non-Small Cell Lung Cancer: Response to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor 5. Brain Metastasis from Non-Small Cell Lung Cancer:  Use of Egfr and Her-2 Status for Targeted Therapy 6. Brain Metastases from Non-Small Cell Lung Cancer:  Current Evidence in Management Using Tyrosine Kinase Inhibitor and Whole Brain Radiation Therapy 7. Brain Metastasis in Patients with Non-Small Cell Lung Cancer:  Immunohistochemical Markers

III.  BREAST CANCER 8. Brain Metastasis from Breast Cancer:  Molecular Mechanisms 9. New Targeted Therapies for Brain Metastasis from Breast and Lung Cancer and Melanoma 10. Breast Cancers with Brain Metastases

IV.  MELANOMA 11. Brain Metastases in Melanoma Patients:  Treatment with Adjuvant Postoperative Whole Brain Radiotherapy 12. Melanoma Progression in the Brain:  Role of Pericytes, the Basal Lamina, and Endothelial Cells in Tumor Vascularization

V.  ESOPHAGEAL CANCER 13. Brain Metastases from Esophageal Cancer in the Presence of Her-2 Overexpression

VI.  RENAL CARCINOMA 14. Brain Metastasis from Renal Carcinoma:  Locoregional and Systemic Treatments

VII.  GASTROINTESTINAL CANCER 15. Gastrointestinal Cancer and Brain Metastasis Outcomes and Management

VIII.  COLORECTAL CANCER 16. Brain Metastasis of Colorectal Cancer:  Microenvironment and Molecular Mechanism

IX.  NASOPHARYNGEAL CARCINOMA 17. Brain Metastasis from Nasopharyngeal Carcinoma