Epigenetics and Neuroplasticity - Evidence and Debate

The ‘epi-(Greek for ‘over’, ‘above’)genome’, with its rich cache of highly regulated, structural modifications—including DNA methylation, histone modifications and histone variants—defines the moldings and three-dimensional structures of the genomic material inside the cell nucleus and serves, literally, as a molecular bridge linking the environment to the genetic materials in our brain cells. Due to technological and scientific advances in the field, the field of neuroepigenetics is currently one of the hottest topics in the basic and clinical neurosciences. The volume captures some of this vibrant and exciting new research, and conveys to the reader an up-to-date discussion on the role of epigenetics across the lifespan of the human brain in health and disease.

Topics cover the entire lifespan of the brain, from transgenerational epigenetics to neurodevelopmental disease to disorders of the aging brain. All chapters are written with dual intent, to provide the reader with a timely update on the field, and a discussion of provocative or controversial findings in the field with the potential of great impact for future developments in the field.

1. The Epigenetic Basis of Memory Formation and Storage
   Timothy J. Jarome, Jasmyne S. Thomas and Farah D. Lubin
2. Epigenetics in Post-Traumatic Stress Disorder.
   Carina Rampp, Elisabeth B. Binder and Nadine Provençal
3. Histone-Mediated Epigenetics in Addiction
   Leah N. Hitchcock and K. Matthew Lattal
4. Modeling the Molecular Epigenetic Profile of Psychosis in Prenatally Stressed Mice
   Alessandro Guidotti, Erbo Dong, Patricia Tueting and Dennis R. Grayson
5. Epigenetics of Depression
   Sermsak Lolak, Pim Suwannarat and Robert H. Lipsky
6. Epigenetic Factors and Intellectual Disability: The Rubinstein-Taybi Syndrome as a Paradigm of Neurodevelopmental Disorder with Epigenetic Origin
   Jose P. Lopez-Atalaya, Luis M. Valor and Angel Barco
7. The Intergenerational Effects of Early Adversity
   Janina Galler and Danielle Galler Rabinowitz
8. The Future of Neuroepigenetics in the Human Brain
   Amanda Mitchell, Panos Roussos, Cyril Peter, Nadejda Tsankova and Schahram Akbarian