Quantitative Human Physiology: An Introduction

Quantitative Human Physiology: An Introduction is the first text to meet the needs of the undergraduate bioengineering student who is being exposed to physiology for the first time, but requires a more analytical/quantitative approach. This book explores how component behavior produces system behavior in physiological systems. Through text explanation, figures, and equations, it provides the engineering student with a basic understanding of physiological principles with an emphasis on quantitative aspects.

Features a quantitative approach that includes physical and chemical principlesProvides a more integrated approach from first principles, integrating anatomy, molecular biology, biochemistry and physiologyIncludes clinical applications relevant to the biomedical engineering student (TENS, cochlear implants, blood substitutes, etc.)Integrates labs and problem sets to provide opportunities for practice and assessment throughout the course

NEW FOR THE SECOND EDITION

Expansion of many sections to include relevant information Addition of many new figures and re-drawing of other figures to update our understanding and clarify difficult areasSubstantial updating of the text to reflect newer research results Addition of several new appendices including statistics, nomenclature of transport carriers, and structural biology of important items such as the neuromuscular junction and calcium release unitAddition of new problems within the problem setsAddition of commentary to power point presentationsWinner of a 2018 Textbook Excellence Award (Texty) from the Textbook and Academic Authors Association

Unit 1: Physical and Chemical Foundations of Physiology

1.1. The Core Principles of Physiology

1.2. Physical Foundations of Physiology I: Pressure-Driven Flow

1.3. Physical Foundations of Physiology II: Electrical Force, Potential, Capacitance, and Current

Problem Set 1.1. Physical Foundations: Pressure and Electrical Forces and Flows

1.4. Chemical Foundations of Physiology I: Chemical Energy and Intermolecular Forces

1.5. Chemical Foundations of Physiology II: Concentration and Kinetics

1.6. Diffusion

1.7. Electrochemical Potential and Free Energy

Problem Set 1.2. Kinetics and Diffusion

Unit 2: Membranes, Transport, and Metabolism

2.1. Cell Structure

2.2. DNA and Protein Synthesis

2.3. Protein Structure

2.4. Biological Membranes

Problem Set 2.1. Surface Tension, Membrane Surface Tension, Membrane Structure, Microscopic Resolution, and Cell Fractionation

2.5. Passive Transport and Facilitated Diffusion

2.6. Active Transport: Pumps and Exchangers

2.7. Osmosis and Osmotic Pressure

Problem Set 2.2. Membrane Transport

2.8. Cell Signaling

2.9. ATP Production I: Glycolysis

2.10. ATP Production II: The TCA Cycle and Oxidative Phosphorylation

2.11. ATP Production III: Fatty Acid Oxidation and Amino Acid Oxidation

Unit 3: Physiology of Excitable Cells

3.1. The Origin of the Resting Membrane Potential

3.2. The Action Potential

3.3. Propagation of the Action Potential

Problem Set 3.1. Membrane Potential, Action Potential, and Nerve Conduction

3.4. Skeletal Muscle Mechanics

3.5. Contractile Mechanisms in Skeletal Muscle

3.6. The Neuromuscular Junction and Excitation–Contraction Coupling

3.7. Muscle Energetics, Fatigue, and Training

Problem Set 3.2. Neuromuscular Transmission, Muscle Force, and Energetics

3.8. Smooth Muscle

Unit 4: The Nervous System

4.1. Organization of the Nervous System

4.2. Cells, Synapses, and Neurotransmitters

4.3. Cutaneous Sensory Systems

4.4. Spinal Reflexes

4.5. Balance and Control of Movement

Problem Set 4.1. Nerve Conduction

4.6. The Chemical Senses

4.7. Hearing

4.8. Vision

4.2 Problem Set. Sensory Transduction

4.9. Autonomic Nervous System

Unit 5: The Cardiovascular System

5.1. Overview of the Cardiovascular System and the Blood

5.2. Plasma and Red Blood Cells

5.3. White Blood Cells and Inflammation

5.4. The Heart as a Pump

Problem Set 5.1. Blood

5.5. The Cardiac Action Potential

5.6. The Electrocardiogram

5.7. The Cellular Basis of Cardiac Contractility

5.8. The Cardiac Function Curve

Problem Set 5.2. Cardiac Work

5.9. Vascular Function: Hemodynamics

5.10. The Microcirculation and Solute Exchange

5.11. Regulation of Perfusion

5.12. Integration of Cardiac Output and Venous Return

5.13. Regulation of Arterial Pressure

Problem Set 5.3. Hemodynamics and Microcirculation

Unit 6: Respiratory Physiology

6.1. The Mechanics of Breathing

6.2. Lung Volumes and Airway Resistance

6.3. Gas Exchange in the Lungs

Problem Set 6.1. Airway Resistance and Alveolar Gas Exchange

6.4. Oxygen and Carbon Dioxide Transport

6.5. Acid–Base Physiology I: The Bicarbonate Buffer System and Respiratory Compensation

6.6. Control of Ventilation

Problem Set 6.2. Gas Transport and pH Disturbances

Unit 7: Renal Physiology

7.1. Body Fluid Compartments

7.2. Functional Anatomy of the Kidneys and Overview of Kidney Function

7.3. Glomerular Filtration

Problem Set 7.1. Fluid Volumes, Glomerular Filtration, and Clearance

7.4. Tubular Reabsorption and Secretion

7.5. Mechanism of Concentration and Dilution of Urine

7.6. Regulation of Fluid and Electrolyte Balance

7.7. Renal Component of Acid–Base Balance

Problem Set 7.2. Fluid and Electrolyte Balance and Acid–Base Balance

Unit 8: Gastrointestinal Physiology

8.1. Mouth and Esophagus

8.2. The Stomach

8.3. Intestinal and Colonic Chemoreception and Motility

8.4. Pancreatic and Biliary Secretion

8.5. Digestion and Absorption of the Macronutrients

8.6. Energy Balance and Regulation of Food Intake

Problem Set 8.1. Energy Balance

Unit 9: Endocrine Physiology

9.1. General Principles of Endocrinology

9.2. Hypothalamus and Pituitary Gland

9.3. The Thyroid Gland

9.4. The Endocrine Pancreas and Control of Blood Glucose

9.5. The Adrenal Cortex

9.6. The Adrenal Medulla and Integration of Metabolic Control

9.7. Calcium and Phosphorus Homeostasis I: The Calcitropic Hormones

9.8. Calcium and Phosphorus Homeostasis II: Target Tissues and Integrated Control

9.9. Female Reproductive Physiology

9.10. Male Reproductive Physiology

Problem Set 9.1. Ligand Binding