The Role of 5-HT Systems on Memory and Dysfunctional Memory: Emergent Targets for Memory Formation and Memory Alterations

Drugs acting through 5-HT (5-hydroxytryptamine, or serotonin) systems modulate memory and its alterations, but the mechanisms by which they do so are poorly understood. Agonists and antagonists for 5-HT receptors, as well as serotonin uptake inhibitors, present promnesic (memory-promoting) and/or anti-amnesic effects under different conditions, and 5-HT receptors are also associated with neural changes. The Role of 5-HT Systems on Memory and Dysfunctional Memory: Emergent Targets for Memory Formation and Memory Alterations reviews and summarizes the most recent research related to 5-HT drugs and the mechanisms by which they effect alterations in memory. This latest evidence is reviewed in the context of memory deficits related to brain disorders, such as post-traumatic stress disorder, schizophrenia, post-stroke cognitive dysfunctions, Parkinson’s disease, and infection-induced memory impairments. Written by an expert in the field of memory, The Role of 5-HT Systems on Memory and Dysfunctional Memory provides an introduction to the latest research on 5-HT receptors and their contributions to the physiological and pharmacological basis of memory.

Examines and summarizes the recent advances in drugs that act through the 5-HT systemsReviews findings in the context of brain disorders that involve memory deficitsCovers emergent targets for memory formation and memory alterations

1. Introduction
2. 5-HT Systems and Neurobiological Markers Related to Memory Systems
3. 5-HT Pathways, Receptors and Transporter: Memory Functions and Dysfunctions
4. 5-HT1A Receptor
5. 5-HT1B Receptor
6. 5-HT1E/1F Receptor
7. 5-HT2A/2B/2C Receptor
8. 5-HT3 Receptor
9. 5-HT4 Receptor
10. 5-HT5 Receptor
11. 5-HT6 Receptor
12. 5-HT7 Receptor
Conclusions