Translating Epigenetics to the Clinic

Translating Epigenetics to the Clinic reviews current methodological tools and experimental approaches used by leading translational researchers seeking to use epigenetics as a clinical model. It organizes epigenetics into disease treatment areas with a major focus on oncology, and with much coverage of pervasive treatment categories such as diabetes, as well as the ‘diseases of modernity’—including pharmacological addiction, dementia, and ageing.

Pedagogically, the work concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field. The book promotes cross-disciplinary communication between the sub-specialties of medicine. In common with the rest of the books in Translational Medicine, the book remains unified in theme by emphasizing recent innovations, critical barriers to progress, and the new tools being used to overcome them. Also includes specific areas of research that require additional study to advance the field as a whole.

Encompasses the latest innovations and tools being used to apply epigenetics in the lab and clinicFeatures extensive pedagogical updates aiming to improve the education of translational researchers in this fieldOffers a transdisciplinary approach to support cross-fertilization between different sub-specialties of medicine

1. Introduction (TBA)
2. Epigenetics and muscle function in COPD (Esther Barreiro, M.D., Ph.D.)
3. Epigenetics of pulmonary fibrosis (David Schwartz, MD; Ivana Yang, PhD)
4. Epigenetics in acute kidney injury and renal cancer (Gregory Dressler, Ph.D.)
5. Epigenetic mechanisms of carcinogenesis (Max Costa, Ph.D.)
6. Epigenetics of epithelial-to-mesenchymal-transition in breast cancer (Sonja C. Stadler, PhD)
7. Maria E. Figueroa, M.D. (Epigenetics of leukemia)
8. Epigenetics of diabetes (Carmella Evans-Molina, MD, PhD)
9. Epigenetic control of fetal hemoglobin (Gordon D. Ginder, MD)
10. Nucleosome remodeling and deacetylase (NuRD) complex in development and disease (Michael Rauchman, MD)
11. RNA epigenetics (Tao Pan, PhD)
12. Epigenetics in immune-related diseases (Xiao-Feng Yang, MD, PhD, FAHA)
13. Epigenetics of dementia in aging (David A. Bennett, MD)
14. Epigenetics of aging (TBA)
15. Epigenetics of stem cell reprogramming (TBA)
16. Epigenetics in cardiovascular disease (TBA)
17. Epigenetics and nutrition (TBA)
18. Epigenetic effects of drug use (TBA)
19. Epigenetics of inflammation (TBA)
20. Epigenetics of lung cancer (TBA)
21. Epigenetics and mitochondria (TBA)