Osteoimmunology: Interactions of the Immune and Skeletal Systems

Osteoimmunology: Interactions of the Immune and Skeletal Systems, Second Edition, explores the advancements that have been made in the field during the last 40 years, including valuable information on our understanding of the interactions between hematopoietic, immune, and bone cells, now known as the field of osteoimmunology.

This comprehensive work offers the most extensive summaries of research trends in the field and their translation into new therapeutics.

Early chapters deal with the development of osteoblasts, osteoclasts, hematopoietic stem cells, T and B-lymphocytes, and communications between these cellular elements, while later sections contain discussions of the signaling pathways by which RANKL influences osteoclast development and function. Subsequent chapters explore the effects that estrogen has on bone and the immune system, the development of pathologic conditions, and the growing research around osteoporosis, Paget’s disease, the genetics of bone disease, and bone cancer metastasis.

Explains the intricate interaction between the immune system and boneFeatures detailed discussions of the key cellular and molecular mechanisms governing the homeostasis of the individual systemsFacilitates greater understanding of osteoimmunologic networks, their environments, and how this understanding leads to better treatments for human diseases involving both systems

1. Overview

2. Origins of the Osteoclast

3. Trafficking of Osteoclast Precursors

4. Osteoclast Biology: Regulation of Formation and Function

5. Osteoblasts and the Immune system

6. Osteocyte Biology

7. Bone Cells and the Hematopoietic Niche

8. The Function of RANKL Beyond the Osteoclast

9. The Effects of Immune Cell Products (Cytokines and Hematopoietic Cell Growth Factors) on Bone Cells

10. Coupling Between Immune and Bone Cells

11. The Role of the Immune System in the Development of Osteoporosis and Fracture Risk

12. The Role of Sex Steroiods in the Interactions of the Immune System with Bone

13. The Role of the Immune System in the Local and Systemic Bone Loss of Inflammatory Arthritis

14. Osteoarthritis and the Immune System

15. Inflammatory Bowel Disease and Bone

16. The Role of the Immune System and Bone Cells in Acute and Chronic Osteomyelitis

17. The Role of the Immune System in Fracture Healing

18. The Role of the Immune System in the Effects of Cancer on Bone

19. Osteoimmunology in the Oral Cavity (Periodontal Disease, Lesions of Endodontic Origin and Orthodontic Tooth Movement)

20. The Role of the Immune System in the Interactions of Fat and Bone