Mesenchymal Stem Cell Derived Exosomes: The Potential for Translational Nanomedicine

Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool.

Introduces the MSC-exosome mediated cell-cell communicationCovers the major functional benefits in current MSC-derived exosome studiesDiscusses strategies for the use of MSC-derived exosomes in cardiovascular therapies

1: Insights into the Mechanism of Exosome Formation and Secretion

2: An Overview of the Proteomic and miRNA Cargo in MSC Derived Exosomes

3: Exosome Function in miRNA-Mediated Paracrine Effects

4: Current Methods in Purification of MSC-Derived Exosomes

5: Stem Cell Extracellular Vesicles: A Novel Cell-Based Therapy for Cardiovascular Diseases

6: The Cardioprotection of Mesenchymal Stem Cell and Anti-Apoptotic microRNA Transfer Through Exosomes

7: Engineered/Hypoxia-Preconditioned MSCs Derived Exosome: Potential Therapeutic Applications

8: Exosome-Based Translational Nanomedicine: The Therapeutic Potential for Drug Delivery

9: Effect of Exosomes from Mesenchymal Stem Cells on Angiogenesis

10: Exosomes for Bone Diseases

11: Diagnostic and Prognostic Applications of MicroRNA-Abundant Circulating Exosomes