Inflammation in Heart Failure

Inflammation in Heart Failure, edited by W. Matthijs Blankesteijn and Raffaele Altara, is the first book in a decade to provide an in-depth assessment on the causes, symptoms, progression and treatments of cardiac inflammation and related conditions. This reference uses two decades of research to introduce new methods for identifying inflammatory benchmarks from early onset to chronic heart failure and specifically emphasizes the importance of classifying at-risk subgroups within large populations while determining the patterns of cytokines in such classifications. Further, the book details clinical applications of the pathophysiological mechanisms of heart failure, diagnosis and therapeutic strategies. Inflammation in Heart Failure’s breadth of subject matter, easy-to-follow structure, portability, and high-quality illustrations create an accessible benefit for researchers, clinicians and students.

Presents updated information and research on the relevant inflammatory mediators of heart failure to aid in targeting future translational research as well as the improvement of early diagnosis and treatmentProvides research into better understanding the different inflammatory mediators that signal the underlying diseases that potentially lead to heart failureContains 20 years of research, offering a brief overview of the topic leading to current opinions on, and treatment of, heart failureProvides a structured, systematic and balanced overview of the role of inflammation in heart failure making it a useful resource for researchers and clinicians, as well as those studying cardiovascular diseases

Preface Section 1  Pathophysiology of the inflammatory response in heart failure Chapter 1: Inflammation in HFpEF Chapter 2: Role of the innate immune system in ischemic heart failure Chapter 3: The role of inflammation in myocardial infarction Chapter 4: Crosstalk between inflammation and extracellular matrix Chapter 5: Crosstalk between brain and inflammation Chapter 6: Translation of animal models into clinical practice: application to heart failure   Section 2  Inflammatory biomarkers Chapter 7: Inflammatory biomarkers in post-infarction heart failure and cardiac remodeling  Chapter 8: Technological aspects of measuring inflammatory markers Chapter 9: Molecular imaging to identify the vulnerable plaque – From basic research to clinical practice  Section 3  Targeting of the inflammatory response Chapter 10: Mineralcorticoid receptor antagonists Chapter 11: PPARs as modulators of cardiac metabolism and inflammation Chapter 12: Inflammatory modulation by statins and heart failure: From pharmacological data to clinical evidence Chapter 13: Small but smart—microRNAs in the centre of inflammatory processes during cardiovascular diseases, the metabolic syndrome, and ageing Chapter 14: The role of cytokines in clinical heart failure