Organic Chemistry of Enzyme-Catalyzed Reactions, Revised Edition

The Organic Chemistry of Enzyme-Catalyzed Reactions is not a book on enzymes, but rather a book on the general mechanisms involved in chemical reactions involving enzymes. An enzyme is a protein molecule in a plant or animal that causes specific reactions without itself being permanently altered or destroyed.

This is a revised edition of a very successful book, which appeals to both academic and industrial markets.

Illustrates the organic mechanism associated with each enzyme-catalyzed reactionMakes the connection between organic reaction mechanisms and enzyme mechanismsCompiles the latest information about molecular mechanisms of enzyme reactionsAccompanied by clearly drawn structures, schemes, and figuresIncludes an extensive bibliography on enzyme mechanisms covering the last 30 yearsExplains how enzymes can accelerate the rates of chemical reactions with high specificityProvides approaches to the design of inhibitors of enzyme-catalyzed reactionsCategorizes the cofactors that are appropriate for catalyzing different classes of reactionsShows how chemical enzyme models are used for mechanistic studiesDescribes catalytic antibody design and mechanismIncludes problem sets and solutions for each chapter Written in an informal and didactic style

Enzymes as Catalysts
Group Transfer Reactions: Hydrolysis, Amination, Phosphorylation
Reduction and Oxidation
Monooxygenation
Dioxygenation
Substitutions
Carboxylations
Decarboxylation
Isomerizations
Eliminations and Additions
Aldol and Claisen Reactions and Retroreactions
Formylations, Hydroxymethylations, and Methylations
Rearrangements
Appendix I Enzyme Kinetics
Appendix II Problems and Solutions