Strategies and Tactics in Organic Synthesis

A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of its practitioners. First hand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought and/or good fortune give rise to successful completion of a project. In this book we learn how synthesis is really done and are educated, challenged and inspired by these stories, which portray the idea that triumphs do not come without challenges. We also learn that we can meet challenges to further advance the science and art of organic synthesis, driving it forward to meet the demands of society, in discovering new reactions, creating new designs and building molecules with atom and step economies that provide solutions through function to create a better world.

* Presents state-of-the-art developments in organic synthesis
* Provides insight and offers new perspective to problem-solving
* Written by leading experts in the field

Chapter 1. The Total Synthesis Of
Luzopeptins.

Chapter 2. Synthesis of Geldanamycin
Using Glycolate Aldol Reactions.

Chapter 3. From Methylene Bridged Glycoluril
Dimers To Cucurbit[N]Uril Analogs With Some Detours Along The Way.

Chapter 4. Application Of Silicon-Assisted
Intramolecular Cross-Coupling In
Total Synthesis Of (+)-Brasilenyne.

Chapter 5. Samarium(II) Promoted Ketyl Olefin
Cyclizations Applied To The Total
Syntheses Of (-)-Steganone And
(+)-Isoschizandrin.

Chapter 6. The Synthesis Of Polycavernoside A.
An Example Of Conformationally Guided
Macrolactonization.

Chapter 7. First Total Synthesis Of Several Natural
Products Based On Alkyne-Co2(Co)6 Complexes.

Chapter 8. Total Synthesis Of Myriaporones 1, 3, and 4.

Chapter 9. Adventures In Natural Product Synthesis:
From Deep Sea Sponge To Pilot Plant. The Large Scale Total Synthesis Of The Marine
Natural Product (+)-Discodermolide.

Chapter 10. Synthesis Of Aprepitant.

Chapter 11. Total Synthesis And Mechanism Of Action Studies On The Antitumor Alkaloid,(-)-Agelastatin A.

Chapter 12. Design And Synthesis of Cooperative "Pinwheel" Fluorescent Sensors.

Chapter 13. Functionalization Of Pyridines And
Thiazoles Via The Halogen-Dance Reaction,
Application To The Total Synthesis Of
Caerulomycin C And WS75624 B.

Chapter 14. Diastereoselective Intramolecular
4+3 Cycloaddition And An Enantioselective
Total Synthesis Of (+)-Dactylol.