Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis, Volume 3 provides detailed accounts of interesting advances in the field of synthesis. This book discusses the tasks of multistep synthesis from finding the proper reagents, reaction, and conditions for individual steps to inventing new chemistry to fill gaps in existing synthetic methodology.

Organized into 13 chapters, this volume begins with an overview of the development of redox glycosidation strategy through ester methylenation. This text then examines the development of computer-assisted molecular modeling with applications to a wide range of problems in biological and organic chemistry. Other chapters consider the medicinal significance of ginkgo tree, which has prompted systematic studies to correlate the claimed beneficial effects of its extracts to the active principles. This book discusses as well the biological potency of pentacyclic quassinoids. The final chapter deals with the economic synthesis of a penem antibacterial.

This book is a valuable resource for chemists.

A.G.M. Barrett, Redox Glycosidation: A Stereoselective Synthesis of Sucrose. R.K. Boeckman, Jr., Solution of Complex Stereochemical Problems with the Aid of Molecular Mechanics-Based Modeling: An Application to the Total Synthesis of (+)-Pleuromutilin. M.C. Desai, A.K. Ghosh, M. Kang, and I.N. Houpis, Total Synthesis of (+)-Ginkgolide B. B. Ganem, Synthetic Studies on Pentacyclic Quassinoids. R.A. Holton, Total Synthesis of Taxusin: An Initial Step toward Taxol Synthesis. P. Kocie*aanski, K. Jarowicki, S. Marczak, and T.M. Willson, Three and One-Half Approaches to the Synthesis of Pederin. S.V. Ley and A. Armstrong, The Champagne Route to Avermectins and Milbemycins. G. Majetich, The Total Synthesis of (+)-Neolemnane and (+)-14-Deoxyisoamijiol: "The Rest of the Story." J.A. Marshall, Synthesis of Cembranoid Natural Products by Intramolecular SE' Additions of Allylic Stannanes to Ynals. R.G. Salomon, Synthesis of Cancer Growth-Inhibiting Diterpene: Spatol. J.A. Ragan, R.F. Standaert, and S.L. Schreiber, Total Synthesis of the FK506/FKBP Complex. R.P. Volante, Total Synthesis of (-)FK506. R.A. Volkmann and B.T. O'Neill, An Industrial Perspective on Total Synthesis; Penem Antibacterial CP-70,429. Chapter References. Index.