Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies

Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies takes a look at the current strategies, successes and challenges involved with the development of novel formulations of biologics, vaccines and cancer therapy. This thorough reference on the latest trends in the development of diverse modalities will appeal to a broad community of scientists, students and clinicians. Written by leading authors across academia and industry, this book covers important topics such as unique drug delivery devices, non-parenteral delivery trends, novel approaches to the treatment of cancer, immunotherapy and more. It includes real-world cases and examples which highlight formulations with therapeutic proteins, monoclonal antibodies, peptides and biobetters, as well as cases on novel vaccines formulations including evolving pathogens, novel modalities of vaccines, universal vaccines. This book is a thorough and useful resource on the development of novel biologics, vaccines and cancer therapies.

Provides strategies for the development of safe and efficacious novel formulations for various modalities of biologics, vaccines and for cancer therapyHighlights novel cases from current clinical trials as well as marketed productsReviews overall successes and challenges in the development of novel formulations, including new molecular targets for the treatment of diseases, design of target-specific therapies, regulatory considerations, individualized therapies

Section I: NOVEL THERAPEUTIC APPROACHES 1. Clinical Considerations in the Design, Evaluation and Development of Novel Therapies 2. New Era in Gene Therapy 3. Advances in Nanotechnology-Based Drug Delivery Platforms and Novel Drug Delivery Systems 4. Novel Approaches for the Delivery of Biologics to the Central Nervous System 5. Trends in Nonparenteral Delivery of Biologics, Vaccines and Cancer Therapies

Section II: NOVEL APPROACHES FOR BIOLOGICS 6. Novel Generation of Antibody-Based Therapeutics 7. Novel Approaches in Discovery and Design of Antibody-Based Therapeutics 8. Novel Therapeutic Proteins and Peptides 9. Biobetter Biologics

Section III: NOVEL APPROACHES FOR VACCINES 10. Vaccines Against Non-Infectious, Non-Cancer Novel Targets 11. Winning a Race Against Evolving Pathogens with Novel Platforms and Universal Vaccines 12. Prime-Boost Vaccination: Impact on the HIV Vaccine Field

Section IV: NOVEL APPROACHES FOR CANCER THERAPIES

IV.I Novel Therapeutic Approaches and Targets for Cancer 13. Personalized Therapies for Cancer Treatment 14. Hunting Molecular Targets for Anticancer Reagents by Chemical Proteomics

IV.II Novel Immunotherapies for Cancer 15. Cancer Vaccines 16. T-Cell Immunotherapy for Cancer 17. Immunostimulators and Immunomodulators in Cancer Treatment

IV.III Novel Approaches for Cancer Therapy with Small Molecules 18. Long-Circulating Therapies for Cancer Treatment 19. Recent Advances and Trends in the Brain Delivery of Small Molecule Based Cancer Therapies