Animal Biotechnology: Models in Discovery and Translation

Animal Biotechnology introduces applications of animal biotechnology and implications for human health and welfare. It begins with an introduction to animal cell cultures and genome sequencing analysis and provides readers with a review of available cell and molecular tools. Topics here include the use of transgenic animal models, tissue engineering, nanobiotechnology, and proteomics. The book then delivers in-depth examples of applications in human health and prospects for the future, including cytogenetics and molecular genetics, xenografts, and treatment of HIV and cancers. All this is complemented by a discussion of the ethical and safety considerations in the field.

Animal biotechnology is a broad field encompassing the polarities of fundamental and applied research, including molecular modeling, gene manipulation, development of diagnostics and vaccines, and manipulation of tissue. Given the tools that are currently available and the translational potential for these studies, animal biotechnology has become one of the most essential subjects for those studying life sciences.

Highlights the latest biomedical applications of genetically modified and cloned animals with a focus on cancer and infectious diseasesProvides firsthand accounts of the use of biotechnology tools, including molecular markers, stem cells, and tissue engineering

Section I: Human Diseases: In Vivo and In Vitro Models Drosophilia: A Model for Biotechnologists; Animal Models of Tuberculosis; Animal Models for Neurodegenerative Disorders; Epigenetics and Animal Models: Applications in Cancer Control and Treatment; Development of Mouse Models for Cancer Research; Human Papillomavirus (HPV): Diagnosis and Treatment; Human DNA Tumor Viruses and Oncogenesis; Animal Models for Human Disease; HIV Antiretroviral Drugs; Animal Biotechnology as a Tool to Understand and Fight Aging;

Section II: Animal Biotechnology: Tools and Techniques MultiCellular Spheroid: 3-D Tissue Culture Model for Cancer Research; Animal Tissue Culture: Principles and Applications; Concepts in Tissue Engineering; Nanotechnology and Its Applications to Animal Biotechnology; Antibodies: Monoclonal and Polyclonal; Molecular Markers: Tool for Genetic Analysis; Gene Expression: Analysis and Quantitation; Ribotyping: A Tool for Molecular Taxonomy; Next Generation Sequencing and Its Applications; Biomolecular Display Technology: A New Tool for Drug Discovery; In Silico Models: From Simple Networks to Complex Diseases;

Section III: Applications and Concerns Transgenic Animals and their Applications; Stem Cells: A Trek from Laboratory to Clinic to Industry; Role of Cytogenetics and Molecular Genetics in Human Health and Medicine; Antibodies and their Applications; Vaccines: Present Status and Applications; Safety Assessment of Food Derived from Genetically Modified Crops; Nanotechnology and Detection of Microbial Pathogens; Biotechnological Exploitation of Marine Animals; Herbal Medicine and Biotechnology for the Benefit of Human Health; Perspectives on the Human Genome; Ethical Issues in Animal Biotechnology