Metal Related Neurodegenerative Disease

This issue reviews the role of metals in neurodegenerative diseases; including Parkinson’s and Huntington’s disease; restless leg syndrome and NBIA disorders; and Wilson’s disease and manganese and calcium accumulation disorders. An update on advances in neuroimaging and pathology of metal related disease is also presented.

This volume of International Review of Neurobiology brings together cutting-edge research on metal related neurodegenerative diseaseIt reviews the role of metals in neurodegenerative diseases, including Parkinson’s and Huntington’s disease; restless leg syndrome and NBIA disorders; and Wilson’s disease and manganese and calcium accumulation disordersAn update on advances in neuroimaging and pathology of metal related disease is also presented

1. Editorial: Metal-Related Neurological Disorders: Several New Genes and Better Understanding

Susanne A. Schneider and Kailash P. Bhatia

2. The Relevance of Metals in the Pathophysiology of Neurodegeneration, Pathological Considerations

Kurt A. Jellinger

3. Pantothenate Kinase-Associated Neurodegeneration (PKAN) and PLA2G6-Associated Neurodegeneration (PLAN): Review of Two Major Neurodegeneration with Brain Iron Accumulation (NBIA) Phenotypes

Manju A. Kurian and Susan J. Hayflick

4. Mitochondrial Membrane Protein-Associated Neurodegeneration (MPAN)

Monika Hartig, Holger Prokisch, Thomas Meitinger and Thomas Klopstock

5. BPAN: The Only X-Linked Dominant NBIA Disorder

Tobias B. Haack, Penny Hogarth, Allison Gregory, Holger Prokisch and Susan J. Hayflick

6. Neuroferritinopathy

Michael J. Keogh, Christopher M. Morris and Patrick F. Chinnery

7. Aceruloplasminemia—An Update

Satoshi Kono

8. Therapeutic Advances in Neurodegeneration with Brain Iron Accumulation

Giovanna Zorzi and Nardo Nardocci

9. The Neuropathology of Neurodegeneration with Brain Iron Accumulation

Michael C. Kruer

10. Imaging of Iron

Petr Dusek , Monika Dezortova and Jens Wuerfel

11. The Role of Iron Imaging in Huntington’s Disease

Simon J. A. van den Bogaard, Eve M. Dumas and Raymund A.C. Roos

12. Lysosomal Storage Disorders and Iron

Jose Miguel Bras

13. Manganese and the Brain

Karin Tuschl, Philippa B. Mills and Peter T. Clayton

14. Update on Wilson Disease

Annu Aggarwal and Mohit Bhatt

15. An Update on Primary Familial Brain Calcification Roberta R. Lemos, J. B. M. M. Ferreira, Matthew P. Keasey and Joao R. M. Oliveira