Diet-Microbe Interactions in the Gut: Effects on Human Health and Disease

Drawing on expert opinions from the fields of nutrition, gut microbiology, mammalian physiology, and immunology, Diet-Microbe Interactions for Human Health investigates the evidence for a unified disease mechanism working through the gut and its resident microbiota, and linking many inflammation-related chronic diet associated diseases. State of the art post-genomic studies can highlight the important role played by our resident intestinal microbiota in determining human health and disease. Many chronic human diseases associated with modern lifestyles and diets — including those localized to the intestinal tract like inflammatory bowel disease and celiac disease, and more pervasive systemic conditions such as obesity, diabetes and cardiovascular disease — are characterized by aberrant profiles of gut bacteria or their metabolites. Many of these diseases have an inflammatory basis, often presenting with a chronic low-grade systemic inflammation, hinting at persistent and inappropriate activation of inflammatory pathways. Through the presentation and analysis of recent nutrition studies, this book discusses the possible mechanisms underpinning the disease processes associated with these pathologies, with high fat diets appearing to predispose to disease, and biologically active plant components, mainly fiber and polyphenols, appearing to reduce the risk of chronic disease development.

One comprehensive, translational source for all aspects of nutrition and diet's effect on gastrointestinal health and diseaseExperts in nutrition, diet, microbiology and immunology take readers from the bench research (cellular and biochemical mechanisms of vitamins and nutrients) to new preventive and therapeutic approachesClear presentations by leading researchers of the cellular mechanisms underlying diet, immune response, and gastrointestinal disease help practicing nutritionists and clinicians (gastroenterologists, endocrinologists) map out new areas for clinical research and structuring clinical recommendations

1. The Microbiota of the Human Gastrointestinal Tract: A Molecular View
2. A Nutritional Anthropology of the Human Gut Microbiota
3. Probiotic Microorganisms for Shaping the Human Gut Microbiota - Mechanisms and Efficacy into the Future
4. Bifidobacteria of the Human Gut: Our Special Friends
5. Shaping the Human Microbiome with Prebiotic  Foods - Current Perspectives for Continued Development
6. Bioactivation of High-Molecular-Weight Polyphenols by the Gut Microbiome
7. Gut Microbial Metabolism of Plant Lignans: Influence on Human Health
8. Gut Microbiome Modulates Dietary Xenobiotic Toxicity: The Case of DON and Its Derivatives
9. Gut Microbiota-Immune System Crosstalk: Implications  for Metabolic Disease
10. The Interplay of Epigenetics and Epidemiology in Autoimmune  Diseases: Time for Geoepigenetics
11. Obesity-Associated Gut Microbiota: Characterization and Dietary Modulation
12. An Apple a Day Keeps the Doctor Away - Inter-Relationship Between Apple Consumption, the Gut Microbiota and CardioMetabolic Disease Risk Reduction
13. Whole Plant Foods and Colon Cancer Risk
14. Population Level Divergence from the Mediterranean Diet and the Risk of Cancer and Metabolic Disease
15. Diet and the Gut Microbiota - How the Gut:Brain Axis Impacts on Autism