Principles of Developmental Genetics

Providing expert coverage of all major events in early embryogenesis and the organogenesis of specific systems, and supplemented with representative clinical syndromes, Principles of Developmental Genetics, Second Edition discusses the processes of normal development in embryonic and prenatal animals, including humans. The new edition of this classic work supports clinical researchers developing future therapies with its all-new coverage of systems biology, stem cell biology, new technologies, and clinical disorders. A crystal-clear layout, exceptional full-color design, and bulleted summaries of major takeaways and clinical pathways assist comprehension and readability of the highly complex content.

All-new coverage of systems biology and stem cell biology in context of evolving technologies places the work squarely on the modern sciencesChapters are complemented with a bulleted summary for easy digestion of the major points, with a clinical summary for therapeutic applicationClinical highlights provides a bridge between basic developmental biology and clinical sciences in embryonic and prenatal syndromes

Section I: Emerging Technologies and Systems Biology 1. Untangling the Gordian knot: Cell signaling events that instruct development 2. RNA-seq and deep sequencing 3. Using mutagenesis in mice and zebrafish for developmental gene discovery 4. Chemical approaches to control stem cell fate 5. BMP signaling and stem cell self-renewal in the Drosophila ovary 6. Genomic Analyses of Neural Stem Cells 7. Chordate origins, stem cells and regeneration

Section II: Early Embryology and Morphogenesis 8. Dorsal-ventral axis patterning in insects 9. Building dimorphic forms: an examination of the genetic pathways that intersect embryonic patterning and sex determination 10. Anterior-Posterior patterning in mammals 11. Early development of epidermis and neural tissue 12. Taking the middle road: mesoderm induction and the blastula-gastrula transition 13. Endoderm induction 14. Epithelial branching: mechanisms of patterning and self-organization 15. Lateral line migration

Section III: Organogenesis 16. Neural cell fate determination 17. Retinal development 18. Neural crest determination 19. Determination of preplacodal ectoderm and sensory placodes 20. Olfactory development 21. Inner ear development 22. Molecular genetics of tooth development 23. Induction of the cardiac lineages 24. Blood vessel formation 25. Blood induction and embryonic formation 26. Vertebrate kidney formation: a comparative perspective 27. Development of the genital system 28. Skeletal  development 29. Formation of vertebrate limbs 30. Patterning the embryonic endoderm into presumptive organ domains 31. Pancreas Development and Regeneration

Section IV: Selected Clinical Problems 32. Diaphragmatic embryogenesis and human congenital diaphragmatic defects 33. Genetic and developmental basis of congenital cardiovascular malformations 34. Multiple Roles of T-box genes 35. Craniofacial syndromes: etiology, impact and treatment 36. DeGeorge and related syndromes 37. Neural tube defects