Natural Hosts of SIV: Implication in AIDS

Natural Hosts of SIV: Implications in AIDS thoroughly reviews the possible mechanisms by which African nonhuman primate natural hosts of lentiviruses remain essentially disease-free while other hosts exhibit disease and death. The book ultimately indicates directions for further research and potential translations of this compelling phenomenon into novel approaches to treat and prevent HIV. When Asian non-human primate non-natural hosts are experimentally infected with viruses isolated from African species, disease and death normally results. Meanwhile, these African nonhuman primate natural hosts maintain similar levels of plasma and cellular viremia and exhibit compellingly different, essentially disease-free, states. This work attempts to answer the question of how the natural host remains disease resistant.

Summarizes the past 30 years of research in this field and describes the latest developments in AIDS research using nonhuman primate animal modelsProvides insights into how this large body of scientific work can be translated into novel approaches to treat and prevent HIVHighlights the areas that merit future pursuit, focusing on potential applications for the treatment and prevention of HIV infection

1. Overview   Aftab Ansari and Guido Silvestri 2. Historical perspective   Preston Marx 3. SIV infections in the wild   Cristian Apetrei and Martine Peeters 4. Virology of SIVs   Frank Kirchhoff 5. SIV infection of chimpanzees   Jonathan Heeney, Edward James Donald Greenwood and Fabian Schmidt 6. Pathology of acute & chronic infection   Francois Villinger and Sanjeev Gumber 7. Mucosal immunity   Jason Brenchley 8. Innate immunity   Steven E. Bosinger and R. Keith Reeves 9. Humoral immune responses   Cynthia Ann Derdeyn and Reinhard Kurth 10. Cellular immune responses   Amitinder Kaur 11. Chronic immune activation   Donald Sodora 12. Pattern of infected cells   Mirko Paiardini and Thomas Howerton Vanderford V 13. Viral transmission   Ivona Pandrea and Ann Chahroudi 14. Genetics of the host   Lutz Walter 15.  The different modes of HIV/SIV control in monkeys and humans   Lisa Chakrabarti 16. Humans resembling natural hosts   Amalio Telenti and Paul McLaren Epilogue: Implications for HIV infection   Aftab Ansari and Guido Silvestri