Biological DNA Sensor: The Impact of Nucleic Acids on Diseases and Vaccinology

Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines.

Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete and concise picture on the topic so you can understand this area of study and make more informed choices for your respective research needs. Chapters are authored by researchers who are renowned for their research focus, ensuring that this book provides the most complete views on the topics.

Multi-authored by a distinguished panel of world-class expertsIdeal source of information for those wanting to learn about DNA sensingProvides in-depth explanations of DNA sensing pathways and the innate immune system, bridging the gap between them

1. Route to discovering the immunogenic properties of DNA from TLR9 to cytosolic DNA sensors Choon Kit Tang, Cevayir Coban, Shizuo Akira, Ken J Ishii 2. The PYHIN family of molecules and their functions sensing dsDNA Sivapriya Kailasan Vanaja, Vijay A. K. Rathinam, Katherine A. Fitzgerald 3. The central role of STING-TBK1 in the DNA sensing pathway Glen Barber    4. Regulation of intracellular dsDNA-induced innate immune responses by autophagy-related proteins Running title: Autophagy and dsDNA-induced innate immunity Tatsuya Saitoh 5. Host DNA Induced Inflammation and Autoimmune Diseases Surya Pandey, Taro Kawai 6. Systemic lupus erythematosus and the DNA sensing pathway Ann Marshak-Rothstein    7. Bacterial infections and the DNA sensing pathway Jan Naujoks, Bastian Opitz 8. Viral infections and the DNA sensing pathway: lessons from herpesviruses and beyond Søren R. Paludan, Andrew G. Bowie 9. Cancer Pathogenesis and DNA sensing Shen Y.J., Lam A.R., Ho S.S.W., Koo C.X., Le Bert N., Gasser S. 10. Atherosclerosis and Aging and DNA sensing  Moshe Arditi 11. DNA Vaccines: Does it Target the Double Stranded-DNA Sensing Pathway? Cevayir Coban, Miyuki Tozuka, Nao Jounai, Kouji Kobiyama, Fumihiko Takeshita, Choon Kit Tang, Ken J. Ishii 12. Adjuvants targeting the DNA sensing pathways – Alum based adjuvants Christophe J. Desmet 13. Adjuvants Targeting the DNA Sensing Pathways– Cyclic-di-GMP and Other Cyclic-di-Nucleotides Rebecca Schmidt, Laurel L. Lenz