Current Concepts in Drug Metabolism and Toxicology

This new volume of Advances in Pharmacology explores the current concepts in drug metabolism and toxicology. Chapters cover the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike.

Explores the current concepts in drug metabolism and toxicologyChapters cover such areas as the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicityAn essential resource for pharmacologists, immunologists and biochemists alike

1. Membrane Transporters in Drug Development
2. The Keap1-Nrf2 Cell Defence Pathway - A Promising Therapeutic Target?
3. Animal Models of Idiosyncratic Drug Reactions
4. Genetic Polymorphisms Affecting Drug Metabolism: Recent Advances and Clinical Aspects
5. Arylamine N-Acetyltransferases - from Drug Metabolism and Pharmacogenetics to Identification of Novel Targets for Pharmacological Intervention
6. Human Pluripotent Stem Cells for Modelling Toxicity
7. Disposition of Biologics