The Proteasomal System in Aging and Disease

This volume of Progress in Molecular Biology and Translational Science discusses cutting-edge research of proteasomes and proteasome-associated proteins and cellular systems. The volume is split into two sections. The first part discusses the current knowledge of the structure, function, and regulation of the proteasomal system. The second part describes the role of the proteasome in aging and disease.

Contributions from leading authoritiesInforms and updates on all the latest developments in the field

1. Structure of the Proteasome

Tobias Jung and Tilman Grune

2. Structure and Function of the Ubiquitin-Proteasome System: Modulation of Components

Niki Chondrogianni and Efstathios S. Gonos

3. Immunoproteasomes: Structure, Function, and Antigen Presentation

Deborah A. Ferrington and Dale S. Gregerson

4. Interactions of the Proteasomal System with Chaperones – Protein Triage and Protein Quality Control

Marc Kästle and Tilman Grune

5. Proteasome Inhibitors

Boris Cvek

6. Degradation of Damaged Proteins - The Main Function of the 20S Proteasome

Andrew. M. Pickering and Kelvin. J. A. Davies

7. Changes of the Proteasomal System During the Aging Process

Martin A. Baraibar and Bertrand Friguet

8. Proteasome and Cancer

Betul Catalgol

9. The Ubiquitin Proteasome System and Cardiovascular Disease.

Saul R. Powell, Joerg Herrmann, Amir Lerman, Cam Patterson, Xuejun Wang

10. Role of the Ubiquitin-Proteasome in Protein Quality Control and Signaling: Implication in the Pathogenesis of Eye Diseases

Fu Shang and Allen Taylor

11. Proteasome and Neurodegeneratıve Dıseases

Betul Catalgol and Tilman Grune