From Molecules to Networks: An Introduction to Cellular and Molecular Neuroscience

An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. The third edition of From Molecules to Networks provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells. In keeping with previous editions, the unique content focus on cellular and molecular neurobiology and related computational neuroscience is maintained and enhanced.

All chapters have been thoroughly revised for this third edition to reflect the significant advances of the past five years. The new edition expands on the network aspects of cellular neurobiology by adding new coverage of specific research methods (e.g., patch-clamp electrophysiology, including applications for ion channel function and transmitter release; ligand binding; structural methods such as x-ray crystallography).

Written and edited by leading experts in the field, the third edition completely and comprehensively updates all chapters of this unique textbook and insures that all references to primary research represent the latest results.

The first treatment of cellular and molecular neuroscience that includes an introduction to mathematical modeling and simulation approaches80% updated and new contentNew Chapter on "Biophysics of Voltage-Gated Ion Channels"New Chapter on "Synaptic Plasticity"Includes a chapter on the Neurobiology of DiseaseHighly referenced, comprehensive and quantitativeFull color, professional graphics throughoutAll graphics are available in electronic version for teaching purposes

SECTION I. CELLULAR AND MOLECULAR 1. Cellular Components of Nervous Tissue - Patrick R. Hof, Graham Kidd, Javier DeFelipe, Jean de Vellis, Miguel A. Gama Sosa, Gregory A. Elder and Bruce D. Trapp 2. Subcellular Organization of the Nervous System: Organelles and Their Functions - Scott Brady and Peter Brophy 3. Energy Metabolism in the Brain - Gerald Dienel 4. Intracellular Signaling - Howard Schulman 5. Regulation of Neuronal Gene Expression and Protein Synthesis - Cristina Alberini and Eric Klann 6. Modeling and Analysis of Intracellular Signaling Pathways - Paul D. Smolen, Douglas A. Baxter and John H. Byrne 7. Pharmacology and Biochemistry of Synaptic Transmission: Classical Transmitters - Ariel Y. Deutch and Robert H. Roth 8. Nonclassic Signaling in the Brain - Ariel Y. Deutch, Andrea Giuffrida and James L. Roberts 9. Connexin- and Pannexin-Based Channels in the Nervous System: Gap Junctions and More - Juan C. Sáez and Bruce Nicholson 10. Neurotransmitter Receptors - M. Neal Waxham 11. Molecular Properties of Ion Channels - Jason Tien, Yuh Nung Jan and Lily Yeh Jan

SECTION II.  PHYSIOLOGY OF ION CHANNELS, EXCITABLE MEMBRANES AND SYNAPTIC TRANSMISSION 12. Membrane Potential and Action Potential - David A. McCormick 13. Biophysics of Voltage-Gated Ion Channels - Diane Lipscombe 14. Dynamical Properties of Excitable Membranes - Douglas A. Baxter and John H. Byrne 15. Release of Neurotransmitters - Robert S. Zucker, Dimitri M. Kullmann and Pascal S. Kaeser 16. Postsynaptic Potentials and Synaptic Integration - John H. Byrne 17. Cable Properties and Information Processing in Dendrites - Michael Beierlein

SECTION III.  INTEGRATION 18. Synaptic Plasticity - Ruth Heidelberger, Harel Shouval, Robert S. Zucker and John H. Byrne 19. Information Processing in Neural Networks - James J. Knierim 20. Learning and Memory: Basic Mechanisms - John H. Byrne, Kevin S. LeBar, Joseph LeDoux, Glenn E. Schafe and Richard F. Thompson 21. Molecular Mechanisms of Neurological Disease - Monica Gireud, Natalie Sirisaengtaksin and Andrew J. Bean