Between the Lines of Genetic Code: Genetic Interactions in Understanding Disease and Complex Phenotypes

Between the Lines of Genetic Code lays out methodologies and tools for the measurement and evaluation of gene-gene and gene-environment studies and gives perspective on the future of this discipline. The book begins by defining terms for interaction studies, describing methodologies, and critically assessing the viability of current study designs and the possibilities for integrating designs. It then provides recent applications data with case studies in rheumatoid arthritis, multiple sclerosis, myositis and other complex human diseases. Last, it examines current studies and directions for future applications in patient care.

Recent multivariate studies show that gene-gene and gene-environment interactions can explain significant variances in inheritance that have previously been undetectable in univariate analysis. These links among genes and between genes and their environments during the development of diseases may serve as important hints for understanding pathogenic mechanisms and for developing new tools for prognosis, diagnosis, and treatment of various diseases.

Systematically integrates methods of defining and detecting gene interactions to provide an overview of the fieldCritically analyzes current methods and tools to aid researchers in integrating gene interaction studies Includes examples of current biomedical applications and presents current research expected to shape clinical research in the near future

1. Introduction
Leonid Padyukov

 

Methodology
2. Terminology and definitions for interaction studies 
Henrik Källberg and Camilla Bengtsson

3. Multidimensional reduction in study of interaction 
Marylyn Ritchie

4. Study design for interaction 
Henrik Källberg and Camilla Bengtsson

5. High throughput interaction study 
Bo Ding and Henrik Källberg

6. Conclusions for the section
Leonid Padyukov

 

Experimental Data
7. Interaction in study of human complex diseases: Rheumatoid arthritis
Lars Klareskog and Lars Alfredsson

8. Interaction in study of human complex diseases: Multiple sclerosis
Ingrid Kockum and Tomas Olsson

9. Interaction in study of human complex diseases: Myositis
Hector Chinoy, Ingrid Lundberg and Robert G. Cooper

10. Interaction in study of human complex diseases: other
Leonid Padyukov and Ingrid Kockum

11. Conclusions for the section
Leonid Padyukov

 

Future Avenues
12. Functional studies of detected interactions in rheumatoid arthritis
Leonid Padyukov

13. Complex patterns of interaction, genetic vectors
Igor Sandalov and Leonid Padyukov

14. From detection to understanding: pathways and networks 
Jesper Nils Tegner

15. Conclusions for the section
Leonid Padyukov

 

Conclusions for the book
16. Conclusions for the book
Leonid Padyukov