Cancer Genomics: From Bench to Personalized Medicine

Cancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase in cancer genomics research and ever-increasing availability of genomic testing are not without significant ethical issues, which are addressed in the context of the return of research results and the legal considerations underlying the commercialization of genomic discoveries. Finally, the book concludes with "Future Directions", examining the next great challenges to face the field of cancer genomics, namely the contribution of non-coding RNAs to disease pathogenesis and the interaction of the human genome with the environment.

Tools such as sidebars, key concept summaries, a glossary, and acronym and abbreviation definitions make this book highly accessible to researchers from several fields associated with cancer genomics.Contributions from thought leaders provide valuable historical perspective to relate the advances in the field to current technologies and literature.

Introduction
1. Historical Overview
  Robert J. Arceci, Jason N. Berman and Graham Dellaire

Methodological Approaches and Background
2. Expression Arrays (SNPs, etc.)
  Stephen Chanock and Javed Khan 
3. Tissue micro-arrays (breast, ovarian)
  Anne-Marie Mes-Masson and Anthony Magliocco 
4. Next generation sequencing (DNAseq) 
  Marco Marra, Sam Aparicio and Elizabeth Chun 
5. RNAseq (breast cancer, sarcomas)
  Stephen B. Montgomery and Ryan D. Morin 
6. Epigenetic Analyses
  Ross Levine
7. Pharmcogenomics
  Shahrad Rod Rassekh and Colin Ross 
8. Biomarker discovery through genomics 
  Janet Dancey
9. Preclinical models for genomics (cell culture, transgenic animals, xenografts) 
  Priscilla Chiu, Jason N. Berman and Graham Dellaire 
10. Bioinformatics and computational methods for data analysis
  Steve J.M. Jones
11. Genomic Resource Projects – The Cancer Genome Atlas (TCGA) International Cancer Genome Consortium (ICGC)
  Jinghui Zhang

Ethics of Genomics Research  
12. Ethics of Genomics Research  
  Conrad Fernandez and Matthew Herder

The Genomics, Epigenomics and Transcriptomics of Cancer
13. Somatic mutations, Transcription and Epigenetics Overview
  Robert J. Arceci, Jason N. Berman and Graham Dellaire 
Adult Solid Tumors
14. Lung Cancer
  Zhaolin Xu
15. Breast Cancer
  Moamen Bydoun, Paola Marcato and Graham Dellaire 
16. Prostate Cancer
  Robert G. Bristow and Fred Saad 
17. Colon Cancer
  Carman Giacomantonio and Daniel Gaston 
18. Thyroid Cancer
  Angela Greco
Age Non-specific Tumors and Hematopoietic Malignancies
19. ALL 
  Charles Mullighan
20. AML
  Soheil Meshinchi and Robert J. Arceci 
21. NHL
  Thomas G. Gross and Nathanael Glen Bailey 
22. Multiple Myeloma
  Kenneth Anderson, Francesca Cottini and Tonon Giovanni 
23. Brain Tumors
  Sheila Singh
Pediatric Cancers
24. Neuroblastoma
  Daniel Morgenstern
25. Soft tissue sarcomas
  Poul H.B. Sorensen
26. Osteosarcoma
  Rama Khokha
27. Wilms Tumors
  Peter Hohenstein and Elizabeth Perlman

Germline Mutations and Hereditary Cancer Syndromes 
28. Germline Mutations and Hereditary Cancer Syndromes
  David Malkin

Future Directions
29. The role of microRNAs and ultraconserved non-coding RNAs in cancer
  George A. Calin
30. Environmental impact on cancer genomics
  Louise Parker