Signal Transduction

A reference on cellular signaling processes, the third edition of Signal Transduction continues in the tradition of previous editions, in providing a historical overview of how the concept of stimulus-response coupling arose in the early twentieth century and shaped our current understanding of the action of hormones, cytokines, neurotransmitters, growth factors and adhesion molecules. In a new chapter, an introduction to signal transduction, the book provides a concise overview of receptor mechanisms, from receptor – ligand interactions to post-translational modifications operational in the process of bringing about cellular changes. The phosphorylation process, from bacteria to men, is discussed in detail.

Signal transduction third edition further elaborates on diverse signaling cascades within particular contexts such as muscle contraction, innate and adaptive immunity, glucose metabolism, regulation of appetite, oncogenic transformation and cell fate decision during development or in stem cell niches. The subjects have been enriched with descriptions of the relevant anatomical, histological, physiological or pathological condition.

In-depth insight into a subject central to cell biology and fundamental to biomedicine, including the search for novel therapeutic interventionsEssential signaling events embedded in rich physiological and pathological contextsExtensive conceptual colour artwork to assist with comprehension of key topicsSpecial emphasis on how molecular structure determines protein function and subcellular localizationEmployment of unambiguous protein names (symbols) in agreement with leading protein- and gene databases, allowing the learner to extend his/her exploration on the web

1. Prologue: Signal Transduction from a Historical Perspective 2. An Introduction to Signal Transduction 3. Regulation of Muscle Contraction by Receptors 4. Cholinergic Signaling and Muscle Contraction 5. Sensory Signal Processing; Visual Transduction and Olfaction 6. Intracellular Calcium 7. Bringing the Signal into the Nucleus: Regulation of Gene Expression 8. Nuclear Receptors 9. Protein Kinase C and Oncogenic Transformation and Cell Polarity 10. Regulation of Cell Proliferation by Receptor Tyrosine Protein Kinases 11. Signal Transduction to and from Adhesion Molecules 12. WNT Signaling and the Regulation of Cell Adhesion and Differentiation 13. Activation of the Innate Immune System: the Toll-Like Receptor-4 and Signaling through Ubiquitylation 14. Chemokines and Traffic of White Blood Cells 15. Activating the Adaptive Immune System: Role of Non-receptor Tyrosine Kinases 16. Signaling through the Insulin Receptor: Phosphoinositide 3-Kinases and AKT 17. TGFß and Signaling through Receptor Serine/Threonine Protein Kinases 18. Protein Phosphates 19. Cell Fate Determination by Notch