Antibody Fc: Linking Adaptive and Innate Immunity

Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology.

Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells.

Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitroCovers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodiesColor illustrations enhance explanations of the immune system

Part 1: Effector Mechanisms Ch 1: Antibody Dependent Cellular Cytotoxicity Ch 2: Antibody-Dependent Cellular Phagocytosis and its Impact on Pathogen Control Ch 3: Interactions between the Complement System and Fcγ Receptors

Part 2: Effector Cells Ch 4: Natural Killer Cells Ch 5: Phagocytes and Immunoglobulins Ch 6: B Cells

Part 3: FcR Ch 7: Structural Recognition of Immunoglobulins by Fcg Receptors Ch 8: FcγRs Across Species Part 4: Variability of the Fc Domain Ch 9: Human IgG Subclasses Ch 10: Antibody Glycosylation

Part 5: Genetic Associations Ch 11: Activating and Inhibitory FcγRs in Autoimmune Disorders Ch 12: Fcg Receptor Polymorphisms and Susceptibility to Infection Ch 13: Role of IgG Fc Receptors in Monoclonal Antibody Therapy of Cancer

Part 6: Evolving areas Ch 14: Interactions Among Monoclonal Antibody Mechanisms of Action Ch 15: Fc Receptor-Dependent Immunity Ch 16: Fcγ Receptors as Therapeutic Targets Ch 17: Fc Protein Engineering Ch 18: Bacterial Modulation of Fc Effector Functions Ch 19: Pathogenic Exploitation of Fc Activity Ch 20: Mechanisms of Immunoglobulin-Mediated Mucus Entrapment of Pathogens at Various Mucosal Surfaces