Mechanotransduction

Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references.

Volume 126 features in-depth reviews that focus on the tools required to investigate mechanotransduction. Additional chapters focus on how we can use these tools to answer fundamental questions about the interaction of physical forces with cell biology, morphogenesis, and function of mature structures. Chapters in the volume are authored by a unique combination of cell biologists and engineers, providing a range of perspectives on mechanotransduction.

Subcellular tools for activating and measuring mechanotransductive signaling

1. The Detection and Role of Molecular Tension in Focal Adhesion Dynamics Brenton D. Hoffman 2. Single Cell Imaging of Mechanotransduction in Endothelial Cells Shaoying Lu and Yingxiao Wang

Focal adhesions as sensors

3. Focal Adhesions as Sensors Jean-Cheng Kuo 4. Focal Adhesions as Sensors Wolfgang H. Goldmann 5. Mechanical Cues Direct Focal Adhesion Dynamics Kristina Haase, Zeinab Al-Rekabi and Andrew E. Pelling 6. Molecular Mechanisms Underlying the Force-Dependent Regulation of Actin-to-ECM Linkage at the Focal Adhesions Hiroaki Hirata, Masahiro Sokabe and Chwee Teck Lim

Nuclear Mechanisms of Sensing

7. The Cellular Mastermind(?) – Mechanotransduction and the Nucleus Ashley Kaminski, Gregory R. Fedorchak and Jan Lammerding 8. Nuclear Forces and Cell Mechano-Sensing Samer Alam, David B. Lovett, Richard B. Dickinson, Kyle J. Roux and Tanmay P. Lele

Mechano-sensing in Stem Cells

9. From Stem Cells to Cardiomyocytes: The Role of Forces in Cardiac Maturation, Aging, and Disease Gaurav Kaushik and Adam J. Engler 10. Matrix Regulation of Tumor-Initiating Cells Sophie Y. Wong and Sanjay Kumar 11. Biomaterials Approaches in Stem Cell Mechanobiology Nikolche Gjorevski and Matthias Lutolf

Multi-cellular Sensing

12. Mechanotransduction in C. elegans Morphogenesis and Tissue Function Erin J. Cram 13. Mechanical Force Sensing in Tissues Soline Chanet and Adam C. Martin